The endocrine regulation network of growth hormone synthesis and secretion in fish: Emphasis on the signal integration in somatotropes  

作　　者：LI WenSheng & LIN HaoRan State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and the Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China 

出　　处：《Science China(Life Sciences)》2010年第4期462-470,共9页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China (Grant No. 2010CB126302);the Earmarked Fund for Modern Agro-industry Technology Research System for Tilapia;the Agriculture Research Special Funds of 3-49;the National High Technology Research and Development Program of China (Grant No. 2007AA091404) to Dr. Li WenSheng

摘　　要：In teleosts, growth hormone (GH) production is governed by multiple neuroendocrine factors from the hypothalamus and other regulators from the pituitary and peripheral organs. Exploring the principles followed by pituitary somatotropes when differentiating and integrating the signals from these regulators at the cellular and intracellular level is essential for understanding the endocrine regulation network of growth hormone synthesis and secretion in fish. This paper discusses recent advances in the action mechanisms of GH regulation factors, including the neuroendocrine regulators, pituitary level factors and peripheral factors, primarily involved in their receptor systems as well as in post-receptor signal transduction pathways.In teleosts, growth hormone (GH) production is governed by multiple neuroendocrine factors from the hypothalamus and other regulators from the pituitary and peripheral organs. Exploring the principles followed by pituitary somatotropes when differentiating and integrating the signals from these regulators at the cellular and intracellular level is essential for understanding the endocrine regulation network of growth hormone synthesis and secretion in fish. This paper discusses recent advances in the action mechanisms of GH regulation factors, including the neuroendocrine regulators, pituitary level factors and peripheral factors, primarily involved in their receptor systems as well as in post-receptor signal transduction pathways.

关 键 词：FISH growth HORMONE RECEPTOR signal TRANSDUCTION 

分 类 号：S917.4[农业科学—水产科学]