Computational RNomics:Structure identification and functional prediction of non-coding RNAs in silico  

作　　者：ZHENG LingLing & QU LiangHu Key Laboratory of Gene Engineering of the Ministry of Education,State Key Laboratory for Biocontrol,Sun Yat-sen University,Guangzhou 510275,China 

出　　处：《Science China(Life Sciences)》2010年第5期548-562,共15页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos. 30830066 and 30771151);the National Basic Research Program (Grant No. 2005CB724600)

摘　　要：The eukaryotic genome contains varying numbers of non-coding RNA(ncRNA) genes."Computational RNomics" takes a multidisciplinary approach,like information science,to resolve the structure and function of ncRNAs.Here,we review the main issues in "Computational RNomics" of data storage and management,ncRNA gene identification and characterization,ncRNA target identification and functional prediction,and we summarize the main methods and current content of "computational RNomics".The eukaryotic genome contains varying numbers of non-coding RNA(ncRNA) genes."Computational RNomics" takes a multidisciplinary approach,like information science,to resolve the structure and function of ncRNAs.Here,we review the main issues in "Computational RNomics" of data storage and management,ncRNA gene identification and characterization,ncRNA target identification and functional prediction,and we summarize the main methods and current content of "computational RNomics".

关 键 词：NON-CODING RNA EUKARYOTE COMPUTATIONAL RNomics 

分 类 号：Q522[生物学—生物化学]