Overcoming multidrug resistance(MDR) in cancer by nanotechnology  

作　　者：BU HuiHui,GAO Yu & LI YaPing Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China 

出　　处：《Science China Chemistry》2010年第11期2226-2232,共7页中国科学（化学英文版）

基　　金：The National Basic Research Program of China (2010CB934000);the National Natural Science Foundation of China (30925041);Shanghai Nanomedicine Program (0852nm05700)

摘　　要：The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance(MDR) cancer.This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs,deliver chemotherapeutic drugs to target sites,control release of drugs,and reduce the systemic toxicity of drugs in MDR cancer.This review addresses the use of nanotechnology to overcome MDR classified on the bases of the fundamental mechanisms of MDR and various approaches to deliver drugs for treatment of MDR cancer.The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance(MDR) cancer.This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs,deliver chemotherapeutic drugs to target sites,control release of drugs,and reduce the systemic toxicity of drugs in MDR cancer.This review addresses the use of nanotechnology to overcome MDR classified on the bases of the fundamental mechanisms of MDR and various approaches to deliver drugs for treatment of MDR cancer.

关 键 词：NANOTECHNOLOGY nanoparticles MULTIDRUG resistance CHEMOTHERAPEUTIC drugs CANCER drug delivery system 

分 类 号：R319[医药卫生—基础医学]