CHEMOTHERAPEUTIC

作品数:69被引量:197H指数:7
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相关领域:医药卫生更多>>
相关作者:李瑞赵浩如林以宁李彩霞周剑萍更多>>
相关机构:中国药科大学郑州大学复旦大学重庆医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家教育部博士点基金更多>>
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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment
《Nano Research》2025年第1期607-617,共11页Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han 
supported by the National Key Research and Development Program of China(No.2022YFE0107800);National Natural Science Foundation of China(Nos.82373206,and 82073332);Zhejiang Provincial Natural Science Foundation of China(No.LHDMZ24H300002)。
Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drug...
关键词:zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) DOXORUBICIN 
Multi-synergistic chemotherapeutic drug assemblies to activate colorectal cancer immunotherapy by modulating the multilevel immunosuppressive characteristics
《Aggregate》2024年第6期187-201,共15页Rongrong Zheng Chuyu Huang Hangyu Zhou Lixin Zhao Qiuyuan Li Guangmiao Chen Linping Zhao Shiying Li 
Basic and Applied Basic Research Foundation of Guangdong Province,Grant/Award Numbers:2021B1515020043,2023A1515012628;National Natural Science Foundation of China,Grant/Award Numbers:32371394,82302355;Science and Technology Program of Guangzhou,Grant/Award Numbers:2024A04J3324,2024A03J0078;National Key Research and Development Program of China,Grant/Award Numbers:2021YFD1800600,2022YFE0209700。
The life-threatening colorectal cancer exhibits multilevel immunosuppressive characteristics,including low immunogenicity,abnormal cellular metabolism,and acidic immunosuppressive microenvironment.In this work,multi-s...
关键词:colorectal cancer drug assemblies IMMUNOTHERAPY photodynamic therapy tumor metabolism 
Ultra-conservative noncoding RNA uc.243 confers chemo-resistance by facilitating the efflux of the chemotherapeutic drug in ovarian cancer
《BIOCELL》2024年第8期1265-1273,共9页SHAN JIANG XIUFENG LIN YANFEI CHEN XINNING LI JIALI KANG 
Background:Despite improvements in objective response rates to cisplatin-based combination chemotherapy,the majority of advanced ovarian cancer remains suboptimal,resulting in poor survival.it has been found that non-...
关键词:Ultra-conserved non-coding RNA uc.243 Drug efflux Drug transporters Chemoresistance Ovarian cancer 
Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery被引量:2
《Acta Pharmaceutica Sinica B》2024年第5期2077-2096,共20页Cheng Qian Yueke Zhou Teng Zhang Guanglu Dong Mengyao Song Yu Tang Zhonghong Wei Suyun Yu Qiuhong Shen Wenxing Chen Jaesung P.Choi Juming Yan Chongjin Zhong Li Wan Jia Li Aiyun Wang Yin Lu Yang Zhao 
This work was financially supported by the projects of National Natural Science Foundation of China(82003991,82101844,and 82304953);Natural Science Foundation of Jiangsu Province(BK20230744,China);Jiangsu Specially Appointed Professorship Foundation(013038021001,China);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22-2045 and KYCX23-2038,China).
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and ant...
关键词:Salvianic acid A Tumor vascular normalization PKM2 β-Catenin CLAUDIN-5 Endothelial glycolysis Tight junctions DOXORUBICIN 
Prognostic significance of SOX2 for chemotherapeutic patients with oral squamous cell carcinoma
《Journal of Pharmaceutical Analysis》2024年第4期619-621,共3页Xuefeng Zhang Hao Xu Tong Zhou Xiaodong Feng Qianming Chen 
supported by the National Natural Science Foundation of China(Grant No.:82002877);the Scientific Research Foundation for Recruited Talents,West China Hospital of Stomatology,Sichuan University,China(Grant No.:QDJF2019-3);the Fundamental Research Funds for the Central Universities,China(Grant No.:YJ201987);Sichuan Science and Technology Program,China(Grant No.:2021ZYD0090).
Oral squamous cell carcinoma(OSCC)is the most common oral cancers worldwide,accounting for over 90%of all oral malignancies[1].Despite encouraging improvements in therapeutic approaches,including surgical resection,ch...
关键词:SOX2 THERAPEUTIC SQUAMOUS 
Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway被引量:2
《Science China(Life Sciences)》2024年第4期663-679,共17页Yanfang Liu Yan Wang Bing Liu Wenzhong Liu Yuanyuan Ma Yiren Cao Shi Yan Panpan Zhang Lixin Zhou Qimin Zhan Nan Wu 
supported by the National Natural Science Foundation of China (81972842, 82373082, 81988101, 82173152)
Chemoresistance is a significant barrier to effective cancer treatment.Potential mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting genes.Here,w...
关键词:CHEMORESISTANCE lncRNARNA interference ROS CHEMOSENSITIZER 
p53 Contributes to the Chemotherapeutic Drug Doxorubicin-Induced Cell Death in Colorectal Cancer Cell Line HCT116
《Proceedings of Anticancer Research》2024年第1期112-116,共5页Rui Deng 
Doxorubicin is a commonly used chemotherapy drug for cancer treatment,although its effectiveness varies across different cancer types.p53 is a key factor involved in cell death induced by therapeutic agents,and it can...
关键词:P53 DOXORUBICIN Knockdown of p53 
Development of Extraction and Detection Method for a Chemotherapeutic Drug with Phenytoin in Biological Samples
《Advances in Biological Chemistry》2024年第4期103-110,共8页Michael Arnot Nicolas Brice Adan Garcia Victor Lomeli My Phuong Vu Karno Ng 
Dexamethasone is classified as a corticosteroid and is commonly used among cancer patients to decrease the amount of swelling around the tumor. Among patients with cancer, in particular brain tumors, seizures can beco...
关键词:DEXAMETHASONE PHENYTOIN CANCER Drug Interaction Solid Phase Extraction 
Retraction: Toxic chemotherapeutic nutrition of cancer cells by alkaline glucosodiene molecules via targeting metabolic of cancerous tumors: a promising theory for cancer treatment. Cancer Adv. 2023;6:e23010. doi:10.53388/2023623010
《Cancer Advances》2023年第15期1-1,共1页Maher Monir.Akl Amoura Mohammed.Abou El Naga 
Cancer Advance has retracted this article at the request of the corresponding author because there are significant errors in the structure of the compound,which forms the basis of the research.Cancer Advance received ...
关键词:CANCER ALKALINE journal 
Study on the Influencing Factors of Chemotherapeutic-Related Taste Changes in Cancer Patients
《Yangtze Medicine》2023年第2期55-62,共8页Xunya Xiong Zaonv Dong Gaopeng Zhang Jun’e Hu 
Objective: To investigate the current situation of chemotherapy-related taste changes of cancer patients in Jingzhou area, and analyze the influencing factors of chemotherapy-related taste changes of cancer patients. ...
关键词:Cancer Patients CHEMOTHERAPY Taste Change Influencing Factors 
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