New-generation biomedical materials:Peptide dendrimers and their application in biomedicine  

作　　者：GU ZhongWei,LUO Kui,SHE WenChuan,WU Yao & HE Bin National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China 

出　　处：《Science China Chemistry》2010年第3期458-478,共21页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No 50633020);the 973 Program (Grant No 2005CB623903)

摘　　要：Peptide dendrimers are attractive synthetic polymers and have been widely used as a new generation of biomaterials in recent years.Peptide dendrimers,as well as general dendrimers,may be synthesized to reach nano sizes,and display well-defined architectures,highly-branched structures,high density of functional terminal groups,and controllable molecular weights.On the other hand,peptide dendrimers have properties similar to proteins and some special characteristics,such as good biocompatibility,water solubility and resistance to proteolytic digestion.Due to these advantages,peptide dendrimers have received considerable attention in biomedicine.This review focuses on the development of peptide dendrimers with emphasis on their applications both in diagnostics and in therapy.Peptide dendrimers are attractive synthetic polymers and have been widely used as a new generation of biomaterials in recent years.Peptide dendrimers,as well as general dendrimers,may be synthesized to reach nano sizes,and display well-defined architectures,highly-branched structures,high density of functional terminal groups,and controllable molecular weights.On the other hand,peptide dendrimers have properties similar to proteins and some special characteristics,such as good biocompatibility,water solubility and resistance to proteolytic digestion.Due to these advantages,peptide dendrimers have received considerable attention in biomedicine.This review focuses on the development of peptide dendrimers with emphasis on their applications both in diagnostics and in therapy.

关 键 词：PEPTIDE DENDRIMERS MOLECULAR probes DRUG delivery gene delivery 

分 类 号：R318.08[医药卫生—生物医学工程]