Homochiral expression of proteins:a discussion on the natural chirality related to the origin of life  

作　　者：HU PingPing1,2, PENG Li2, ZHEN ShuJun3, CHEN LiQiang2, XIAO SaiJin1 & HUANG ChengZhi1,3 1Key Laboratory on Luminescence Real-Time Analysis, Ministry of Education College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China 2College of Life Science, Southwest University, Chongqing 400715, China 3College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China 

出　　处：《Science China Chemistry》2010年第4期792-796,共5页中国科学（化学英文版）

基　　金：support from the Major State Basie Research Development Program (Grant No. 2006CB933100);the National Natural Science Foundation of China (Grant No. 90813019)

摘　　要：Homochirality in life has always been a driving force in scientific research and natural exploration. It has not been satisfactorily explained, and systematic investigations are necessary. This paper reported a homochiral expression of proteins dependent on the stirring direction of growing media. By controlling the stirring direction clockwise (CW) and anticlockwise (ACW) of the culture medium, proteins with distinct secondary structures were obtained, and D-amino acid may be included in the protein cultured with the stirring direction of ACW. Considering the effect of force fields, which might affect the process of folding and refolding of cellular protein in this report, the control of force fields might be a good way to prepare asymmetric drugs, and the rotational direction of the earth is possibly related to the chirality in primitive life molecules.Homochirality in life has always been a driving force in scientific research and natural exploration. It has not been satisfactorily explained, and systematic investigations are necessary. This paper reported a homochiral expression of proteins dependent on the stirring direction of growing media. By controlling the stirring direction clockwise (CW) and anticlockwise (ACW) of the culture medium, proteins with distinct secondary structures were obtained, and D-amino acid may be included in the protein cultured with the stirring direction of ACW. Considering the effect of force fields, which might affect the process of folding and refolding of cellular protein in this report, the control of force fields might be a good way to prepare asymmetric drugs, and the rotational direction of the earth is possibly related to the chirality in primitive life molecules.

关 键 词：HOMOCHIRALITY CHIRAL EXPRESSION PRION protein fluorescence 

分 类 号：Q51[生物学—生物化学]