Interaction of bis-aryl functionalized molecules with nucleosides and nucleic acids  

作　　者：HUANG Yu1,LIU JunLiang1,ZHANG Ji1,LIU Qiang1,HOU JiTing1,ZHANG Yu1,ZHANG DaWei2,LU QiaoSen1,CHEN ShanYong1,LIN HongHui2 & YU XiaoQi1 1 Key Laboratory of Green Chemistry and Technology,Ministry of Education College of Chemistry,Sichuan University,Chengdu 610064,China 2 Key Laboratory of Bio-resources and Eco-environment,Ministry of Education College of Life Sciences,Sichuan University,Chengdu 610064,China. 

出　　处：《Science China Chemistry》2010年第1期103-112,共10页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.20725206 and 20732004);Specialized Research Fund for the Doctoral Program of Higher Education;Scientific Fund of Sichuan Province for Outstanding Young Scientists

摘　　要：A series of novel molecules with a cyclen(1,4,7,10-tetraazacyclododecane) moiety appended on and bearing different aromatic fragments in the structures were synthesized and characterized.The binding activities of these compounds towards DNA were systematically studied by spectroscopic,viscometric and gel electrophoresis methods.The results suggest that the stacking interaction plays an important role in improving the DNA binding ability of the compounds.The binding modes of the compounds towards DNA are also affected by the sizes of the aromatic rings.The binding interaction between binaphthyl compound 1b and several nucleosides was studied by fluorescence titration.Stacking interaction and hydrophobic interaction play the key role in such non-selective binding process.A series of novel molecules with a cyclen(1,4,7,10-tetraazacyclododecane) moiety appended on and bearing different aromatic fragments in the structures were synthesized and characterized.The binding activities of these compounds towards DNA were systematically studied by spectroscopic,viscometric and gel electrophoresis methods.The results suggest that the stacking interaction plays an important role in improving the DNA binding ability of the compounds.The binding modes of the compounds towards DNA are also affected by the sizes of the aromatic rings.The binding interaction between binaphthyl compound 1b and several nucleosides was studied by fluorescence titration.Stacking interaction and hydrophobic interaction play the key role in such non-selective binding process.

关 键 词：stacking and HYDROPHOBIC interactions DNA binding AROMATIC compounds NUCLEOSIDES OLIGONUCLEOTIDES 

分 类 号：O629.13[理学—有机化学]