Roles of MAP kinase signaling pathway in oocyte meiosis  

作　　者：Hengyu Fan Chao Tong Dayuan Chen Qingyuan Sun 

机构地区：[1]Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China

出　　处：《Chinese Science Bulletin》2002年第14期1157-1162,共6页

基　　金：This work was supported by the Special Funds for Major State Basic Research ("973") Project of China (Grang No. Gl 999055902); the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KSCX2-SW-303).

摘　　要：Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases expressed widely in eu-karyotic cells. MAPK is activated by a cascade of protein kinase phosphorylation and plays pivotal roles in regulating meiosis process in oocytes. As an important physical substrate of MAPK, p90rsk mediates numerous MAPK functions. MAPK was activated at G2/M transition during meiosis. Its activity reached the peak at M I stage and maintained at this level until the time before the pronuclear formation after fertilization. There is complex interplay between MAPK and MPF in the meiosis regulation. Furthermore, other intracel-lular signal transducers, such as cAMP, protein kinase C and protein phosphotase, ect., also regulated the activity of MAPK at different stages during meiosis in oocytes. In the present article, the roles of MAPK signaling pathway in oo-cyte meiosis are reviewed and discussed.Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases expressed widely in eukaryotic cells. MAPK is activated by a cascade of protein kinase phosphorylation and plays pivotal roles in regulating meiosis process in oocytes. As an important physical substrate of MAPK,p90rsk mediates numerous MAPK functions. MAPK was activated at G2/M transition during meiosis. Its activity reached the peak at M I stage and maintained at this level until the time before the pronuclear formation after fertilization. There is complex interplay between MAPK and MPF in the meiosis regulation. Furthermore, other intracellular signal transducers, such as cAMP, protein kinase C and protein phosphotase, ect., also regulated the activity of MAPK at different stages during meiosis in oocytes. In the present article, the roles of MAPK signaling pathway in oocyte meiosis are reviewed and discussed.

关 键 词：protein KINASE OOCYTE MEIOSIS signal TRANSDUCTION fer-tilization. 

分 类 号：Q55[生物学—生物化学]