Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P-AbPS)  

作　　者：陈晓明 张健 田庚元 

出　　处：《Chinese Journal of Chemistry》2002年第11期1406-1410,1133,共5页中国化学（英文版）

基　　金：theMinistryofScienceandTechnology ,China (No .970 2 110 0 6 4 4 )

摘　　要：The synthesis of phosphorylated Achyranthes bidentata polysaccharide (P-AbPS) was reported based on different strategies. The P-AbPS with high degree of substitution (D.S. > 0.5) was obtained when phosphorus oxychloride (POCl3) was used as a phosphorylating agent and trimethyl phosphate-pyridine or dimethyl formamide was used as solvent. The influences of different solvents and reaction conditions were discussed. The pharmacology assay shows that P-AbPS possesses antitumor activity against sarcoma 180 and Lewis lung cancer in mice.The synthesis of phosphorylated Achyranthes bidentata polysaccharide (P-AbPS) was reported based on different strategies. The P-AbPS with high degree of substitution (D.S. > 0.5) was obtained when phosphorus oxychloride (POCl3) was used as a phosphorylating agent and trimethyl phosphate-pyridine or dimethyl formamide was used as solvent. The influences of different solvents and reaction conditions were discussed. The pharmacology assay shows that P-AbPS possesses antitumor activity against sarcoma 180 and Lewis lung cancer in mice.

关 键 词：PHOSPHORYLATION POLYSACCHARIDE Achyranthes bidentata ANTITUMOR 

分 类 号：O636[理学—高分子化学]