Antitumor mechanism of VP-16: A pulse radiolysis study  

作　　者：汪世龙 王玫 倪亚明 姚思德 李文哲 孙晓宇 刘仕姮 张超杰 

出　　处：《Science China Chemistry》2002年第4期394-397,共4页中国科学（化学英文版）

基　　金：This work was supported by the National Natural Science Foundation of China (Grant No. 39700029).

摘　　要：The antitumor mechanism of etoposide (VP-16) is investigated using pulse radiolysis technology. The oxidizing mechanism of VP-16 is studied by sodium persulfate, and the reaction rate constant is 4.04× 109 L· mol-1 · s-1. The electron-transfer between VP-16 and tyrosine is observed and the reaction rate constant is 1.1 - 108 L · mol-1· s-1.The antitumor mechanism of etoposide (VP-16) is investigated using pulse radiolysis technology. The oxidizing mechanism of VP-16 is studied by sodium persulfate, and the reaction rate constant is 4.04×109 L·mol?1·s ?1. The electron-transfer between VP-16 and tyrosine is observed and the reaction rate constant is 1.1×108 L·mol ?1·s ?1.

关 键 词：podophyllotoxin VP-16 PULSE RADIOLYSIS ANTITUMOR activity. 

分 类 号：R73-36[医药卫生—肿瘤]