Clinical application of radioimmunoi maging with (99)~m　Tc-BDI-1in the diagnosis of bladder cancer  

作　　者：王荣福 张春丽 

出　　处：《Chinese Medical Journal》2000年第5期12-15,共4页中华医学杂志（英文版）

摘　　要：To evaluate the clinical application of radioimmunoimaging (Rll ) with 99m Tc-BDI-1 in thediagnosis of bladder cancer. Methods 32 pstients with bladder cancer and 5 with normal bladder were studied. Rll was performed 1 hour after intravesical administration of 111-222 MBq 99m Tc-BDI-1 followed by washing out and perfusing bladder with 50 ml PBS. The radioactivity ratio of target over background (C T/C B) was calculated. Results The radiochemical purity of 99m Tc-BDI-1 Wasgreater than 95%. Rll showed radioactive accumulation area for most of bladder c0ancers but no radio-active concentration for normal bladder. The sensitivity and specificity were 91 .7% and 81 .8% respectively with the assignment of the positive criterion of C T/C B≥ 1.40. There was no statistical difference in sensitivity between tumors with diameters ≥ 1 cm (1. 0-4.2 cm) and < 1 cm (0.2-0.8 cm). C T/C B was related to the pathological grade (G 1-G 3) of the tumor. Conclusions Rll by intravesical administration provides a new noninvasive method for the diagnosis of bladder cancer in morphology and in nature of tumor with high sensitivity and specificity. It may be used for the early diagnosis of bladder cancer, follow-up after surgery, and diagnosis of in situ tumor.To evaluate the clinical application of radioimmunoimaging (Rll ) with 99m Tc-BDI-1 in thediagnosis of bladder cancer. Methods 32 pstients with bladder cancer and 5 with normal bladder were studied. Rll was performed 1 hour after intravesical administration of 111-222 MBq 99m Tc-BDI-1 followed by washing out and perfusing bladder with 50 ml PBS. The radioactivity ratio of target over background (C T/C B) was calculated. Results The radiochemical purity of 99m Tc-BDI-1 Wasgreater than 95%. Rll showed radioactive accumulation area for most of bladder c0ancers but no radio-active concentration for normal bladder. The sensitivity and specificity were 91 .7% and 81 .8% respectively with the assignment of the positive criterion of C T/C B≥ 1.40. There was no statistical difference in sensitivity between tumors with diameters ≥ 1 cm (1. 0-4.2 cm) and < 1 cm (0.2-0.8 cm). C T/C B was related to the pathological grade (G 1-G 3) of the tumor. Conclusions Rll by intravesical administration provides a new noninvasive method for the diagnosis of bladder cancer in morphology and in nature of tumor with high sensitivity and specificity. It may be used for the early diagnosis of bladder cancer, follow-up after surgery, and diagnosis of in situ tumor.

关 键 词：radioimmunoimaging · bladder neoplasms  · antibody MONOCLONAL 

分 类 号：R737.14[医药卫生—肿瘤]