Cycloaddition of benzoheteroazepine Ⅲ Reaction of 2,3-dihydro-lH-l,5-benzodiazepines with dichlorocarbene and stereo-structures of products  

作　　者：张新宇 许家喜 金声 

机构地区：[1]College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

出　　处：《Chinese Journal of Chemistry》1999年第4期404-410,4,共8页中国化学（英文版）

摘　　要： Reaction of 2,3-dihydro-1H-l,5-benzodiazepines with dichlorocarbene generated in situ using benzyltriethylammonium chloride (TEBA) as a phase transfer catalyst in chloroform-aqueous sodium hydroxide mixture gave mainly 1,2-cycloadducts, as and trans-la,3-disubstituted-1, 1-dichloro-1a,2,3,4-tetrahydro-1H-azirino[l,2-a][l,5]benzodiazepines (2,3), and formylated 1,2-cycloadducts, trans-la,3-disubstituted-l, 1-dichloro-4-formyl-1a,2,3,4-tetrahydro-lH-azirino[l,2-a][l,5]benzodiazepines (4). The stereo-structures of cycloadducts and the mechanism are also discussed.Reaction of 2,3-dihydro-1H-l,5-benzodiazepines with dichlorocarbene generated in situ using benzyltriethylammonium chloride (TEBA) as a phase transfer catalyst in chloroform-aqueous sodium hydroxide mixture gave mainly 1,2-cycloadducts, as and trans-la,3-disubstituted-1, 1-dichloro-1a,2,3,4-tetrahydro-1H-azirino[l,2-a][l,5]benzodiazepines (2,3), and formylated 1,2-cycloadducts, trans-la,3-disubstituted-l, 1-dichloro-4-formyl-1a,2,3,4-tetrahydro-lH-azirino[l,2-a][l,5]benzodiazepines (4). The stereo-structures of cycloadducts and the mechanism are also discussed.

关 键 词：BENZODIAZEPINE azirinobenzodiazepine DICHLOROCARBENE cycloaddition. 

分 类 号：O621.25[理学—有机化学]