脂质体制剂对环胞苷二棕榈酸酯抗癌活性的影响  

Liposomal Dosage Effect on the Antitumor Activity of 3' ,5'-Dipalmitoyl Cyclocytidine

作　　者：王继波[1] 刘玉兰[1] 李珊[1] 侯新朴[2] 徐成 

机构地区：[1]青岛大学医学院,266021 [2]北京医科大学药学院

出　　处：《青岛医药卫生》1999年第2期81-82,共2页Qingdao Medical Journal

基　　金：国家自然科学基金批准号3860328

摘　　要：目的 研究3′,5′-环胞苷二棕榈酸酯(DPC)制成脂质体剂型后其抗癌活性的变化。方法 将DPC制成脂质体剂型,分别与其母体药物阿糖胞苷脂质体和游离的DPC对照进行药效学的研究,比较它们对小鼠腹水型肝癌的抑制率。结果 DPC脂质体的抑制率明显高于阿糖胞苷脂质体(P<0.05);十分明显地高于游离的DPC(P<0.01)。结论 DPC载于脂质体上其抗癌活性明显提高,药物吸收难的问题得以解决。Objective To study the effect of liposomal dosage on the antitumor activity of 3' , 5'-Dipalmitoyl cyclocyti-dine(DPC). Methods DPC was encapsulated in liposome. Pharmacodynamatical studies between DPC liposome and its parent drug Ara-C liposome,unencapsulated DPC were made. The inhibition rates to aseites liver cancer of mice were compared. Results The inhibition rate of DPC liposome was evidently higher than that of Ara-C liposome (P<0. 05),it was also extremely higher than that of free DPC(P<0. 01) Conclusion Liposomes improved the antitumor activity and uptake of DPC.

关 键 词：脂质体 制剂 3′ 5′-环胞苷二棕榈酸酯(DPC) 抗癌活性 

分 类 号：R73-3[医药卫生—肿瘤]