High Efficiency Gene Transfer to Autologous Rabbit Jugular Vein Grafts Using Recombinant Adenovirus-Transferrin/Polylysine-DNA Complexes  

作　　者：刘国庆 朱宇 蔡海江 

出　　处：《The Journal of Biomedical Research》1996年第1期2-6,22,共6页生物医学研究杂志（英文版）

摘　　要：Thesedatashowthathigh-efficientgenetransductioncanbeachievedinautologousveingraftsusingadenovirus-transferin/polylysine-DNAcomplexes.Thismethodoferssomeadvantagesoverrecombinantretrovirusofadenovirusvectors.Exvivogenetherapyofveingraftsmayreducegraftocclusionbytheintroductionandhighlevelexpresionofantithromboticand/orantiproliferativegenes.Thesedatashowthathigh-efficientgenetransductioncanbeachievedinautologousveingraftsusingadenovirus-transferin/polylysine-DNAcomplexes.Thismethodoferssomeadvantagesoverrecombinantretrovirusofadenovirusvectors.Exvivogenetherapyofveingraftsmayreducegraftocclusionbytheintroductionandhighlevelexpresionofantithromboticand/orantiproliferativegenes.

关 键 词：autologousveingrafts GENEEXPRESSION GENETRANSFER adenovirus Β-GALACTOSIDASE 

分 类 号：R394.3[医药卫生—医学遗传学]