Β-GALACTOSIDASE

作品数：33被引量：66H指数：4
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相关领域：生物学医药卫生更多>>
相关作者：罗利朱家壁俞冠翘刘芳华姚宇玫更多>>
相关机构：中国科学院上海生命科学研究院浙江大学医学院附属第一医院罗格斯,新泽西州立大学昆明理工大学更多>>
相关期刊：《Journal of Innovative Optical Health Sciences》《Cancer Biology & Medicine》《Acta Biochimica et Biophysica Sinica》《Food Bioscience》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金浙江省科技厅基金更多>>
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Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence
《Chinese Chemical Letters》2024年第12期378-381,共4页Xu Qu Pengzhao Wu Kaixuan Duan Guangwei Wang Liang-Liang Gao Yuan Guo Jianjian Zhang Donglei Shi 
the financial support from the National Natural Science Foundation of China(Nos.21977082,22037002and 21472148);the Natural Science Basic Research Program of Shaanxi(No.2020JC-38)。
Humanβ-galactosidase(β-gal)is recognized as a crucial biomarker for evaluating senescence at the cellular and tissue levels in humans.However,tools to precisely track the endogenousβ-gal are still limited.Herein,we...
关键词：Senescence associatedβ-galactosidase Dual-emission SELF-CALIBRATION Cell imaging Fluorescent probes 
A near-infrared fluorescent probe for fast and precise imaging of senescent cells and ovarian cancer cells via trackingβ-galactosidase
《Chinese Chemical Letters》2023年第12期456-459,共4页Haiting Pan Xianzhi Chai Junji Zhang 
supported by National Natural Science Foundation of China(Nos.22122803 and 21788102);the National Natural Science Foundation of Jiangsu Province(No.BK20220644).
Aging-related diseases are gradually becoming a major problem with the rapid development of aged population in human society.Although many fluorescent probes have been employed to diagnosis senescence via imaging sene...
关键词：Β-GALACTOSIDASE Near-infrared fluorescent probe Senescent cell Precise imaging Fast response 
A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids被引量：4
《Cancer Biology & Medicine》2023年第7期519-536,共18页Ruixin Yang Yutong Du Wingyan Kwan Ranlin Yan Qimeng Shi Lu Zang Zhenggang Zhu Jianming Zhang Chen Li Yingyan Yu 
supported by grants from the National Natural Science Foundation of China(Grant Nos.82072602 and 82173222);the Science and Technology Commission of Shanghai Municipality(Grant Nos.20DZ2201900 and 18411953100);the Innovation Foundation of Translational Medicine of Shanghai Jiaotong University School of Medicine(Grant No.TM202001);the Collaborative Innovation Center for Clinical and Translational Science of the Chinese Ministry of Education&Shanghai(Grant No.CCTS-2022202)。
Objective:Organoids are a powerful tool with broad application prospects in biomedicine.Notably,they provide alternatives to animal models for testing potential drugs before clinical trials.However,the number of passa...
关键词：Gastric cancer ORGANOIDS cellular senescence senescence-associatedβ-galactosidase artificial intelligence 
In vitro digestibility of oligosaccharides synthesized by dairy propionibacteriaβ-galactosidase from lactose,lactulose and lactitol被引量：1
《Food Bioscience》2023年第1期1248-1254,共7页Agustina Fara Oswaldo Hernandez-Hernandez Antonia Montilla Gabriela Zarate 
supported by EMHE CSIC 2017,PID2021-123862OBI00 from MICINN,PICT-3504 from ANPCyT(Argentina);Project IC-901 from USPT(Argentina).
Prebiotics synthesized by probiotic genera are of interest due to their specific selectivity.However,modifications of their composition and concentrations by digestion may affect their properties and effects in the ho...
关键词：PROPIONIBACTERIA OLIGOSACCHARIDES Brush border membrane vesicles(BBMV)from pig Rat small intestinal extract(RSIE) 
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells被引量：1
《Signal Transduction and Targeted Therapy》2022年第10期3645-3648,共4页Shuaishuai Ni Qian Liu Xin Chen Lele Ding Lili Cai Fei Mao Donglei Shi Robert M.Hoffman Jian Li Lijun Jia 
supported by the National Natural Science Foundation of China(Grant Nos.81820108022,22177076,22037002);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-10-E00056,2021-01-07-00-02-E00104);The Scientific and Technological Innovation Action Plan of Science and Technology Commission of Shanghai(20JC1411300);Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation(2021KJ03-12);National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development(2017ZX09304001);the Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(2021 Sci&Tech 03-28);the Innovative Research Team of High-level Local Universities in Shanghai and the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering(2060204).
Dear Editor,Targeting senescence therapy is a promising anticancer strategy by arresting the cell-cycle and inducing cellular senescence.However,senescent cells can promote malignancy and drug resistance.1,2 Thus,with...
关键词：viable cancer eliminate 
Trends in lactose-derived bioactives:synthesis and purification
《Systems Microbiology and Biomanufacturing》2022年第3期393-412,共20页Carlos Vera Cecilia Guerrero Andrés Illanes 
funded by Projects 11180282 and 1190104;National Research and Development Agency of Chile(ANID).
Lactose obtained from cheese whey is a low value commodity despite its great potential as raw material for the production of bioactive compounds.Among them,prebiotics stand out as valuable ingredients to be added to f...
关键词：Prebiotic LACTOSE Β-GALACTOSIDASE Oligosaccharide purification 
Robust temporal changes of cellular senescence and proliferation after sciatic nerve injury被引量：2
《Neural Regeneration Research》2022年第7期1588-1595,共8页Yin-Ying Shen Rui-Rui Zhang Qian-Yan Liu Shi-Ying Li Sheng Yi 
supported by the National Natural Science Foundation of China,No.31970968(to SYL);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Cellular senescence and proliferation are essential for wound healing and tissue remodeling.However,senescence-proliferation cell fate after peripheral nerve injury has not been clearly revealed.Here,post-injury gene ...
关键词：bioinformatic analysis cellular senescence dorsal root ganglia P16 peripheral nerve regeneration peripheral nerve trauma PROLIFERATION rat sciatic nerves sciatic nerve crush β-galactosidase activities 
A β-galactosidase kiss of death for senescent cells被引量：1
《Cell Research》2020年第7期556-557,共2页Xiaoqian Liu Juan Carlos Izpisua Belmonte Weiqi Zhang Guang-Hui Liu 
In a recent paper published in Cell Research,Cai et al.report development of the prodrug senescence-specific killing compound 1(SSK1),which specifically clears SA-β-galactosidase-positive senescent cells both in vitr...
关键词：INFLAMMATION HOMEOSTASIS predominant 
Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice被引量：21
《Cell Research》2020年第7期574-589,共16页Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng 
This work was supported by National Key Research and Development Program of China(2017YFA0104003,2017YFA0103000);the National Natural Science Foundation of China(22040102 and 31521004 to H.D.and T.L.,31730059 to H.D.,21672011 and 21822101 to T.L.).
Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease ch...
关键词：INFLAMMATION eliminate function 
β-galactosidase responsive AIE fluorogene for identification and removal of senescent cancer cells被引量：2
《Science China Chemistry》2020年第3期398-403,共6页Zhengfeng Gao Heqi Gao Debin Zheng Tengyan Xu Yaoxia Chen Chunhui Liang Ling Wang Dan Ding Zhimou Yang 
supported by the National Key Research and Development Program of China(2017YFC2103502,2017YFE0132200);the Fundamental Research Funds for the Central Universities,the National Natural Science Fundation of China(31870949,31670973);Tianjin Science Fund for Distinguished Young Scholars(17JCJQJC44900).
The selective identification and removal of senescent cells including senescent cancer cells are very important to prolong life and improve the treatment efficacy of cancer therapy.In this study,we integrated the high...
关键词：SENESCENCE cancer fluorescence SELF-ASSEMBLY AGGREGATION induced emission 
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