The Effect of Tetramethylpyrazine on Tumor Necrosis Factor-α,Thromboxane A_2 and Prostecyclin in Cerebrospinal Fluidof Rabbits with Bacterial Meningitis  

作　　者：周克英 黄榕 虞佩兰 张宝林 杨于嘉 周佩芳 

出　　处：《Chinese Journal of Integrative Medicine》1996年第3期215-217,共3页中国结合医学杂志（英文版）

摘　　要：This study aimed to evaluate the effect of tetramethylpyrazine in treating bacterial meningi-tis . Experimental model of rabbit meningitis was induced by intracisternal inoculation ot 2 x 107 colony-formingunits of Escherichia Coli and tumor necrosis factor-a, thromboxane B2 and 6-keto-prostagladin F1a concentra-tions in cerebrospinal fluid of rabbits in different treatment groups were measured at 24 hrs, 27 hrs and 30 hrsafter infection. Results showed that tetramethylpyrazine could significantly lower the concentrations of tumornecrosis factor-a and thromboxane B2 in cerebrospinal fluid. Administration of both tetramethylpyrazine andampicillin could attenuate the antibiotic-induced rapid release of the 2 intlammatory mediators .This study aimed to evaluate the effect of tetramethylpyrazine in treating bacterial meningi-tis . Experimental model of rabbit meningitis was induced by intracisternal inoculation ot 2 x 107 colony-formingunits of Escherichia Coli and tumor necrosis factor-a, thromboxane B2 and 6-keto-prostagladin F1a concentra-tions in cerebrospinal fluid of rabbits in different treatment groups were measured at 24 hrs, 27 hrs and 30 hrsafter infection. Results showed that tetramethylpyrazine could significantly lower the concentrations of tumornecrosis factor-a and thromboxane B2 in cerebrospinal fluid. Administration of both tetramethylpyrazine andampicillin could attenuate the antibiotic-induced rapid release of the 2 intlammatory mediators .

关 键 词：TETRAMETHYLPYRAZINE tumor necrosis factor THROMBOXANE PROSTACYCLIN MENINGITIS cere-brospinal fluid RABBITS 

分 类 号：R73-36[医药卫生—肿瘤]