EFFECT　OF　SPLENECTOMY　OF　GASTRIC　CANCER　INDUCED　WITH　N－METHYL－N＇－NITRO－N　NITROSOGUANIDINE　IN　RATS  

作　　者：朱正纲 尹浩然 燕敏 曹伟新 洪鹤群 林言箴 王瑞年 

出　　处：《Medical Bulletin of Shanghai Jiaotong University》1995年第1期47-51,共5页上海交通大学学报（医学英文版）

摘　　要：The wistar rals were given N-methyl-N-nitro-N-nitrosoguanidine (MNNG), 100μg/ml in tap water,to be given ad libitum for 9 months. A total of 80 outbred male wistar rats were equally divided inio 4 groups:Ⅰsplenectomy+MNNG feeding; Ⅱ, omentumectomy + MNNG feeding;Ⅲ, splenectomy only;Ⅳ.omentumectomy only. Among 80 of the rats 23 died within the first 6 months, no cancerous lesion was found (Ⅰ, 0/4, Ⅱ, 0/4, Ⅲ, 0/10, Ⅳ,0/5). Three of the 14 rats that died during the 7th and 8th months were found to present gastric cancer (GC)outgrowth (Ⅰ, 2/4, Ⅱ, 1/5, Ⅲ, 0/3, Ⅳ, 0/2). The rest of the survivors was sacrificed by the end of the 9th month. Thus, the incidence of the GC outgrowth of the various groups were:Ⅰ,14/16 (87.5%); Ⅱ, 10/16 (62.5%), Ⅲ, 0/10;Ⅳ, 0/15.Besides, the cancerous lesions found in groups Ⅰrats appeared to be significantly aggressive than the group Ⅱ rats in terms of depth of invasion and trmor size. In conclusion, the splenectomized rats presented a higher incidence of GC outgrowth,and tended to develop more aggressive tumors.

关 键 词：GASTRIC CANCER SPLENECTOMY METHYLNITRONITROSOGUANIDINE 

分 类 号：R735.205[医药卫生—肿瘤]