A Facile Synthesis of 4-Alkyl-2-Quinolones  

作　　者：Huang Xian and Ye Fangchen (Department of Chemistry, Hangzhou University, Hangzhou) 

出　　处：《Chemical Research in Chinese Universities》1992年第1期45-47,共3页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China

摘　　要：The derivatives of 4-alkyl-2-quinolones possess a variety of biological activities. The general synthetic method of 4-alkyl-2-quinolones is the reaction of aryl amines with β-ketoesters to form β-ketoamides, which are then heated in concentrated sulfuric acid to complete the ring closure. Although a number of its 4-methyl and aryl derivatives have been obtained, other 4-alkyl-2-quinolones are rarely mentioned for lack of a convenient method to prepare the appropriate β-ketoesters used in condensation.

关 键 词：QUINOLONES Meldrum' s acid ACYLATION AMINOLYSIS Synthesis 

分 类 号：O6[理学—化学]