RESEARCHES ON THE ANTI-AUTOLOGOUS TUMOR EFFECTS OF HUMAN CANCER-KILLING CELLS IN NUDE MICE  

作　　者：张滨学 唐尧 郑杰 殷澄 王洁良 由江峰 方伟岗 吴秉铨 王秀云 高荣莲 

机构地区：[1]Department of Pathology, Beijing Medical University [2]Department of Gyneoology and Obstetrics, the Third Hospital, Beijing Medical University

出　　处：《Chinese Journal of Cancer Research》1992年第4期33-35,共3页中国癌症研究（英文版）

摘　　要：An investigation of human splenic LAK cells killing autologous tumor in vivo has been performed in this study. Briefly, an ovary embryo carcinoma (OEC) removed surgically from patient was transplanted Into nude mice (s. c. ) and cultured in vitro, that would be used as targets. Lymphokine-activated killer (LAK) cells were generated from splenic lymphocytes of the OEC patient, who died two and half months after operation, by co- culture with recombinant human interleukin- 2 ( rIL- 2 ) in vitro. The results from Winn' s test in nude mice suggested that these LAK cells could effectively inhibit the tumorlgenicity of autologous tumor m vitro.An investigation of human splenic LAK cells killing autologous tumor in vivo has been performed in this study. Briefly, an ovary embryo carcinoma (OEC) removed surgically from patient was transplanted Into nude mice (s. c. ) and cultured in vitro, that would be used as targets. Lymphokine-activated killer (LAK) cells were generated from splenic lymphocytes of the OEC patient, who died two and half months after operation, by co- culture with recombinant human interleukin- 2 ( rIL- 2 ) in vitro. The results from Winn' s test in nude mice suggested that these LAK cells could effectively inhibit the tumorlgenicity of autologous tumor m vitro.

关 键 词：lymphokine-activated kilter cells INTERLEUKIN-2 nude mice 

分 类 号：R73[医药卫生—肿瘤]