Beyond white light endoscopy: The role of optical biopsy in inflammatory bowel disease  

作　　者：Julia Liu Aldona Dlugosz Helmut Neumann 

机构地区：[1]Division of Gastroenterology,the Centre of Excellence for Gastrointestinal Inflammation and Immunity Research,University ofAlberta,Alberta T6G 2X8,Canada [2]Division of Gastroenterology and Hepatology,Department of Medicine,Karolinska University Hospital,Karolinska Institutet,SE-141 86 Stockholm,Sweden [3]Department of Medicine 1,Interdisciplinary Endoscopy,University of Erlangen-Nuremberg,91054 Erlangen,Germany

出　　处：《World Journal of Gastroenterology》2013年第43期7544-7551,共8页世界胃肠病学杂志（英文版）

基　　金：Supported by Dr.Julia Liu is a recipient of the Canadian Institute of Health Research New Investigator Salary Award,and funding support from the Canadian Association of Gastroenterology and Crohn’s and Colitis Foundation of Canada;Dr.Aldona Dlugosz is a recipient of the Postdoctoral Fellowship from Stockholm County Council and funding support from the Karolinska Institute Funds;Dr.Helmut Neumann is a recipient of the 2013 American Society for Gastrointestinal Endoscopy Cook Medical Don Wilson Award

摘　　要：In this review,we will discuss the use of two optical biopsy modalities in inflammatory bowel disease(IBD).The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy.We will describe the technical performance of the procedure,discuss the clinical indications for optical biopsy in IBD,and highlight active research areas with respect to the pathogenesis of IBD.Clinical indications for optical biopsies in IBD include assessment of mucosal inflammation,dysplasia detection and evaluation of cell shedding for disease relapse.Research application in the area of barrier dysfunction will also be discussed.In this review, we will discuss the use of two optical biopsy modalities in inflammatory bowel disease (IBD). The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy. We will describe the technical performance of the procedure, discuss the clinical indications for optical biopsy in IBD, and highlight active research areas with respect to the pathogenesis of IBD. Clinical indications for optical biopsies in IBD include assessment of mucosal inflammation, dysplasia detection and evaluation of cell shedding for disease relapse. Research application in the area of barrier dysfunction will also be discussed.

关 键 词：Optical biopsy CONFOCAL ENDOMICROSCOPY ENDOCYTOSCOPY DYSPLASIA MUCOSAL inflammation Disease RELAPSE MUCOSAL healing Barrier function 

分 类 号：R574[医药卫生—消化系统]