Internal carotid thrombus in patients with inflammatory bowel disease:Two cases  

作　　者：Sébastien Richard Gioia Mione Julien Perrin Marie Toussaint-Hacquard Jean-Christophe Lacour Xavier Ducrocq 

机构地区：[1]Department of Neurology,CHU Nancy,Hospital Central,54035 Nancy Cedex,France [2]Department of Biological Hematology,CHU Nancy,hpitaux de Brabois,rue du Morvan,54511 Vandoeuvre-les-Nancy Cedex,France

出　　处：《World Journal of Gastroenterology》2013年第5期773-775,共3页世界胃肠病学杂志（英文版）

摘　　要：Increased ischemic stroke risk is observed in patients with inflammatory bowel disease(IBD).Causes and physiopathological aspects of cerebral infarct,in this specific population,are less often described.There is little information to provide guidelines for the best curative and preventive treatment.We report 2 cases of ischemic strokes due to internal carotid thrombus in patients during active phase of IBD.Ulceration of early atherosclerotic plaques activated by a hypercoagulation state may cause a thrombus.A combined therapy with heparin and corticosteroids was used for both our patients.Lysis of the thrombus was obtained after several days without surgical treatment and shown by ultrasonography.These cases highlight an aetiology of stroke in patients with IBD and use of a synergic treatment to respond to hypercoagulability in link with IBD. Benefits and safety of this therapy should be confirmed with clinical studies.Increased ischemic stroke risk is observed in patients with inflammatory bowel disease (IBD). Causes and physiopathological aspects of cerebral infarct, in this specific population, are less often described. There is little information to provide guidelines for the best curative and preventive treatment. We report 2 cases of ischemic strokes due to internal carotid thrombus in patients during active phase of IBD. Ulceration of early atherosclerotic plaques activated by a hypercoagulation state may cause a thrombus. A combined therapy with heparin and corticosteroids was used for both our patients. Lysis of the thrombus was obtained after several days without surgical treatment and shown by ultrasonography. These cases highlight an aetiology of stroke in patients with IBD and use of a synergic treatment to respond to hypercoagulability in link with IBD. Benefits and safety of this therapy should be confirmed with clinical studies.

关 键 词：Inflammatory BOWEL disease ISCHEMIC stroke CAROTID THROMBUS HYPERCOAGULABLE state ATHEROSCLEROSIS 

分 类 号：R574[医药卫生—消化系统]