Multiple endocrine neoplasia type 1 with upper gastrointestinal hemorrhage and perforation:A case report and review  

作　　者：Ying-Ying Lu Feng Zhu Da-Dao Jing Xie-Ning Wu Lun-Gen Lu Gen-Quan Zhou Xing-Peng Wang 

机构地区：[1]Department of Gastroenterology,Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine [2]Department of Radiology,Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine

出　　处：《World Journal of Gastroenterology》2013年第8期1322-1326,共5页世界胃肠病学杂志（英文版）

摘　　要：Multiple endocrine neoplasia type 1(MEN1) is a rare hereditary syndrome known to predispose subjects to endocrine neoplasms in a variety of tissues such as the parathyroid glands,pituitary gland,pancreas and gastrointestinal tract.We herein report a patient with a past history of pituitary adenoma,presenting with symptoms of chronic diarrhea for nearly one year and a sudden upper gastrointestinal hemorrhage as well as perforation without signs.Nodules in the duodenum and in the uncinate process and tail of pancreas and enlargement of the parathyroid glands were detected on preoperative imaging.Gastroscopy revealed significant ulceration and esophageal reflux diseases.The patient underwent subtotal parathyroidectomy and autotransplantation,pylorus-preserving pancreaticoduodenectomy and pancreatic tail resection and recovered well.The results observed in our patient suggest that perforation and bleeding of intestine might be symptoms of ZollingerEllison Syndrome in patients with MEN1.Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary syndrome known to predispose subjects to endocrine neoplasms in a variety of tissues such as the parathyroid glands, pituitary gland, pancreas and gastrointestinal tract. We herein report a patient with a past history of pituitary adenoma, presenting with symptoms of chronic diarrhea for nearly one year and a sudden upper gastrointestinal hemorrhage as well as perforation without signs. Nodules in the duodenum and in the uncinate process and tail of pancreas and enlargement of the parathyroid glands were detected on preoperative imaging. Gastroscopy revealed significant ulceration and esophageal reflux diseases. The patient underwent subtotal parathyroidectomy and autotransplantation, pylorus-preserving pancreaticoduodenectomy and pancreatic tail resection and recovered well. The results observed in our patient suggest that perforation and bleeding of intestine might be symptoms of Zollinger-Ellison Syndrome in patients with MEN1.

关 键 词：PITUITARY ADENOMA HYPERPARATHYROIDISM GASTRINOMA Gastrointestinal HEMORRHAGE PERFORATION 

分 类 号：R736[医药卫生—肿瘤] R573.2[医药卫生—临床医学]