Intracellular calcium signaling in osteocytes:A mechano-transduction-mechano paradigm  

作　　者：Da Jing X.Lucas Lu Andrew Baik Bin Zhou Xiaonan Lai Liyun Wang X.Edward Guo 

机构地区：[1]Department of Biomedical Engineering,Fourth Military Medical University [2]Bone Bioengineering Laboratory,Department of Biomedical Engineering,Columbia University [3]Department of Mechanical Engineering,University of Delaware

出　　处：《医用生物力学》2013年第S1期23-24,共2页Journal of Medical Biomechanics

基　　金：supported by the US National Institutes of Health grants R21 AR052417,R01 AR052461,RC1 AR058453(XEG),and R01 AR054385(LW)

摘　　要：Osteocytes in vivo are embedded in the mineralized extracellular bone matrix,where their cell bodies reside in the lacunae and are interconnected to neighboring osteocytes through numerous intercellular processes.The 3-dimensional（3D）osteocyte network positioning and ability to communicate with other bone cells make osteocytes ideal mechanosensors of bone.Thus the role of osteocyte network and intercellular communication between osteocytes in response to mechanical stimulation may clarify the mechanisms behind normal bone adaptation to mechanical loading.We have been using intracellular calcium([Ca²⁺]_i)as a ubiquitous real-time signaling indicator for studying mechanotransduction in osteocytic networkOsteocytes in vivo are embedded in the mineralized extracellular bone matrix,where their cell bodies reside in the lacunae and are interconnected to neighboring osteocytes through numerous intercellular processes.The 3-dimensional（3D）osteocyte network positioning and ability to communicate with other bone cells make osteocytes ideal mechanosensors of bone.Thus the role of osteocyte network and intercellular communication between osteocytes in response to mechanical stimulation may clarify the mechanisms behind normal bone adaptation to mechanical loading.We have been using intracellular calcium([Ca2+]i)as a ubiquitous real-time signaling indicator for studying mechanotransduction in osteocytic network and

关 键 词：INTERCELLULAR transduction communicate stimulation signaling clarify NUMEROUS INTRACELLULAR PARADIGM positioning 

分 类 号：R318.08[医药卫生—生物医学工程]