INTRACELLULAR

作品数：426被引量：960H指数：13
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相关领域：医药卫生生物学更多>>
相关作者：李金华郭兆贵康宏建李晓红郭航远更多>>
相关机构：中国科学院北京大学南昌大学第一附属医院中国医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Intracellular calcium channels:Potential targets for type 2 diabetes mellitus?
《World Journal of Diabetes》2025年第4期37-47,共11页Jia-Xuan Zhu Zhao-Nan Pan Dan Li 
Supported by Calygene Biotechnology Inc.,No.XT[2016]008@。
Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosi...
关键词：Ion channels AMP-activated protein kinase CALCIUM DIABETES Lactic acidosis 
Targeting intracellular autophagic process for the treatment of post-stroke ischemia/reperfusion injury
《Animal Models and Experimental Medicine》2025年第3期389-404,共16页Jun Hu Zekai Hu Jiayi Xia Yeping Chen Dennis Cordato Qi Cheng Jie Wang 
Shanghai Rehabilitation Medical Association,Grant/Award Number:2023JGKT24;China Rehabilitation Medical Association,Grant/Award Number:KFKT-2023;Shanghai“14th Five-Year Plan”Traditional Chinese Medicine Specialty and Traditional Chinese Medicine Emergency Capacity Improvement Project,Grant/Award Number:ZYTSZK2-7。
Cerebral ischemia/reperfusion(I/R)injury is an important pathophysiological condition of ischemic stroke that involves a variety of physiological and pathological cell death pathways,including autophagy,apoptosis,necr...
关键词：AUTOPHAGY cerebral ischemia ischemia/reperfusion injury STROKE TREATMENT 
Endogenous Fe^(2+)- triggered self- targeting nanomicelles for self- amplifying intracellular oxidative stress
《Animal Models and Experimental Medicine》2025年第2期307-321,共15页Zhongxiong Fan Guoyu Xia Qingluo Wang Shiduan Chen Jianmin Li Zhenqing Hou Ziwen Jiang Juan Feng 
We acknowledge the financial support from the National Natural Science Foundation of China(82000152);Key Research and Development Program in Xinjiang Uygur Autonomous Region(2023B02030 and 2023B02030-1);Autonomous Region Universities Basic Research Funds Research Projects-Cultivation Projects(XJEDU2023P017);Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01C698);the Xinjiang Uygur Autonomous Region Tianchi Talent Introduction Program-Young Doctor(51052300514).
Background:Artesunate(ASA)acts as an•O_(2)^(-)source through the breakdown of en-doperoxide bridges catalyzed by Fe2+,yet its efficacy in ASA-based nanodrugs is lim-ited by poor intracellular delivery.Methods:ASA–hya...
关键词：nanomicelles non-Fenton oxidative stress reactive oxygen species self-targeting 
Tumor derived cell-free nucleic acid upregulates programmed death-ligand 1 expression in neutrophil via intracellular Toll-like receptor signaling
《Cancer Communications》2025年第1期4-8,共5页Suguru Saito Duo-Yao Cao Tomohiro Shibata Yan Liu Aoi Otagiri-Hoshi Xiaojiang Cui Kenneth E.Bernstein 
supported by the National Institutes of Health grants(R01AI164519,2R01CA151610,R21CA280458);American Heart Association’s Career Development award(23CDA1052548);U.S.Department of Defense(W81XWH-18-1-0067)and the Glazer Foundation.
Neutrophils are innate immune cells that function predominantly against pathogens,while recent studies have revealed additional crucial roles in various diseases,including cancers[1–3].For instance,neutrophils expres...
关键词：DEATH diseases programmed 
The interplay between extracellular and intracellular auxin signaling in plants
《Journal of Genetics and Genomics》2025年第1期14-23,共10页Wenxin Tang Yongqiang Yu Tongda Xu 
supported by the National Natural Science Foundation of China(32130010).
The phytohormone auxin exerts control over remarkable developmental processes in plants.It moves from cell to cell,resulting in the creation of both extracellular auxin and intracellular auxin,which are recognized by ...
关键词：Extracellular auxin signaling Intracellular auxin signaling ABP1/ABLs TMKs TIR1/AFBs 
Intracellular carbon monoxide release unveils selective antibacterial effects被引量：1
《Science China Materials》2024年第12期3849-3860,共12页Tengfei Ma Shaoqiu Zheng Jian Cheng Guoying Zhang Jinming Hu 
supported by the National Natural Scientific Foundation of China(52350348,52233009,52021002,92356302,52273155,and 52073270);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0450301 and XDB0450102);the CAS Project for Young Scientists in Basic Research(YSBR-094);the Joint Funds from Hefei National Synchrotron Radiation Laboratory(KY2060000197);the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP012)。
Carbon monoxide(CO)is recognized as a diffusible and biologically membrane-permeable gasotransmitter.However,the question of whether extracellular and intracellular CO delivery would yield similar or distinct biologic...
关键词：carbon monoxide intracellular release ANTIBACTERIAL ANTI-INFLAMMATION cutaneous abscesses 
Integrated nanoporous electroporation and sensing electrode array for total dynamic time-domain cardiomyocyte membrane resealing assessment
《Bio-Design and Manufacturing》2024年第6期972-982,共11页Weiqin Sheng Ying Li Chunlian Qin Zhonghai Zhang Yuxiang Pan Zhicheng Tong Chong Teng Xinwei Wei 
supported by the Zhejiang Provincial Natural Science Foundation of China(No.LQ23E010004);the National Key Research and Development Program of China(No.2021YFB3200801)。
Intracellular electrophysiological research is vital for biological and medical research.Traditional planar microelectrode arrays(MEAs)have disadvantages in recording intracellular action potentials due to the loose c...
关键词：Nanoporous electrode array(NPEA) ELECTROPORATION Intracellular potential recording CARDIOMYOCYTE Membrane resealing 
Bifunctional nanoprobe for simultaneous detection of intracellular reactive oxygen species and temperature in single cells
《Microsystems & Nanoengineering》2024年第6期161-172,共12页Yanmei Ma Weikang Hu Jian Hu Muyang Ruan Jie Hu Ming Yang Yi Zhang Hanhan Xie Chengzhi Hu 
supported by the National Key Technologies R&D Program of China(Grant No.2023YFC2415900);Guangdong Basic and Applied Basic Research Foundation(No.2024A1515011915,No.2022A1515010098);partly supported by the Science,Technology,and Innovation Commission of Shenzhen Municipality under grant no.ZDSYS20200811143601004;in part by the Stable Support Plan Program of Shenzhen Natural Science Fund under grant 20220815104331001.
Living cells can rapidly adjust their metabolic activities in response to external stimuli,leading to fluctuations in intracellular temperature and reactive oxygen species(ROS)levels.Monitoring these parameters is ess...
关键词：METABOLISM simultaneous holds 
Optimizing ABA-based chemically induced proximity for enhanced intracellular transcriptional activation and modification response to ABA
《Science China(Life Sciences)》2024年第12期2650-2663,共14页Zeng Zhou Yue-Qi Wang Xu-Nan Zheng Xiao-Hong Zhang Lu-Yao Ji Jun-You Han Ze-Cheng Zuo Wei-Liang Mo Li Zhang 
supported by grants from China Postdoctoral Science Foundation (2022TQ0120,2022M721320);the Science and Technology Research Project of the Education Department of Jilin Province,China (JJKH20221036KJ);the Open Project of State Key Laboratory of Supramolecular Structure and Materials (sklssm2023033);Natural Science Foundation of Jilin Province (20240305059YY)。
Abscisic acid(ABA)-based chemically induced proximity(CIP)is primarily mediated by the interaction of the ABA receptor pyrabactin resistance 1-like 1(PYL1)and the 2C-type protein phosphatase ABI1,which confers ABA-ind...
关键词：ABA chemically induced proximity transcriptional activation m^(6)A modification protein evolution 
Supra-and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays
《Microsystems & Nanoengineering》2024年第6期351-361,共11页Shivani Shukla Joshua L.Schwartz Callum Walsh Wen Mai Wong Vrund Patel Yu-Peng Hsieh Chichi Onwuasoanya Shaoming Chen Andreas Offenhäusser Gert Cauwenberghs Francesca Santoro Alysson R.Muotri Gene W.Yeo Sreekanth H.Chalasani Zeinab Jahed 
supported by the Air Force Office of Scientific Research YIP award(AFOSR FA9550-23-1-0090);UC San Diego Materials Research Science and Engineering Center(UC San Diego MRSEC),supported by the National Science Foundation(Grant DMR-2011924)to Z.J;performed at the San Diego Nanotechnology Infrastructure(SDNI)of UCSD,a member of the National Nanotechnology Coordinated Infrastructure,which was supported by the National Science Foundation(Grant ECCS-2025752);supported by NIH grants MH107367 and MH131907 to G.W.Y;Runyon Cancer Research Foundation Fellowship to WM;the Hewitt Foundation fellowship to CW;R01NS115591 and Mathers Foundation grants to SC;National Science Foundation CCF-2208771 to GC.
The brain integrates activity across networks of interconnected neurons to generate behavioral outputs.Several physiological and imaging-based approaches have been previously used to monitor responses of individual ne...
关键词：RECORDING networks RECORD 
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