Targeting intracellular autophagic process for the treatment of post-stroke ischemia/reperfusion injury  

作　　者：Jun Hu Zekai Hu Jiayi Xia Yeping Chen Dennis Cordato Qi Cheng Jie Wang 

机构地区：[1]Department of Traditional Rehabilitation,The Second Rehabilitation Hospital of Shanghai,Shanghai,China [2]The Clinical Research Centre,The Second Rehabilitation Hospital of Shanghai,Shanghai,China [3]Department of Neurology and Neurophysiology,Liverpool Hospital,Sydney,New South Wales,Australia [4]Stroke and Neurology Research Group,Ingham Institute for Applied Medical Research,Sydney,New South Wales,Australia

出　　处：《Animal Models and Experimental Medicine》2025年第3期389-404,共16页动物模型与实验医学(英文)

基　　金：Shanghai Rehabilitation Medical Association,Grant/Award Number:2023JGKT24;China Rehabilitation Medical Association,Grant/Award Number:KFKT-2023;Shanghai“14th Five-Year Plan”Traditional Chinese Medicine Specialty and Traditional Chinese Medicine Emergency Capacity Improvement Project,Grant/Award Number:ZYTSZK2-7。

摘　　要：Cerebral ischemia/reperfusion(I/R)injury is an important pathophysiological condition of ischemic stroke that involves a variety of physiological and pathological cell death pathways,including autophagy,apoptosis,necroptosis,and phagoptosis,among which autophagy is the most studied.We have reviewed studies published in the past 5 years regarding the association between autophagy and cerebral I/R injury.To the best of our knowledge,this is the first review article summarizing potential candidates targeting autophagic pathways in the treatment of I/R injury post ischemic stroke.The findings of this review may help to better understand the pathogenesis and mechanisms of I/R events and bridge the gap between basic and translational research that may lead to the development of novel therapeutic approaches for I/R injury.

关 键 词：AUTOPHAGY cerebral ischemia ischemia/reperfusion injury STROKE TREATMENT 

分 类 号：R74[医药卫生—神经病学与精神病学]