Stem cells:two sides of the coin  

作　　者：Tingting Tang 

机构地区：[1]Shanghai Key Laboratory of Orthopaedic Implants,Department of Orthopaedic Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine

出　　处：《医用生物力学》2013年第S1期65-66,共2页Journal of Medical Biomechanics

基　　金：supported by grants from the National Natural Science Foundation of China (10872131,81172549,31271015);a grant from the Shanghai Science and Technology Development Fund (11XD1403300);the key disciplines program of the Shanghai Municipal Education Commission(J50206)

摘　　要：Bone marrow derived mesenchymal stem cells(MSCs)have been widely used to promote the repair or regeneration of damaged tissues.In previous studies,we have developed several stem cells based strategies to promote the bone repair,which includes the BMP-2 gene medicine,construction of tissue engineering bone in bioreactor and clinical trial of enriched stem cell therapy.Among these studies,one challenge is to construct the tissue engineered bone at the large scale which face the problem of poor survivor of seeding cells in the scaffold interior.In our studies,the porousβ-TCP cylindrical scaffolds loading with MSCs were continuously perfused by a customized bioreactor(dynamic culture)at different flow rate or were immersedBone marrow derived mesenchymal stem cells(MSCs)have been widely used to promote the repair or regeneration of damaged tissues.In previous studies,we have developed several stem cells based strategies to promote the bone repair,which includes the BMP-2 gene medicine,construction of tissue engineering bone in bioreactor and clinical trial of enriched stem cell therapy.Among these studies,one challenge is to construct the tissue engineered bone at the large scale which face the problem of poor survivor of seeding cells in the scaffold interior.In our studies,the porousβ-TCP cylindrical scaffolds loading with MSCs were continuously perfused by a customized bioreactor(dynamic culture)at different flow rate or were immersed in

关 键 词：repair BIOREACTOR SCAFFOLD engineered enriched immersed INTERIOR porous CHALLENGE REGENERATION 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]