Mechanobiology of airway smooth muscle cells and its regulations in pathogenesis of asthma  

作　　者：Linhong Deng 

机构地区：[1]Institute of Biomedical Engineering and Health Sciences,Changzhou University

出　　处：《医用生物力学》2013年第S1期104-106,共3页Journal of Medical Biomechanics

基　　金：supported by National Natural Science Foundation of China(Grant No. 11172340);Training Program for Hundreds of Distinguished Leading Scientists of Chongqing;Chongqing Natural Science Foundation(Grant No.CSTC2010BA5001,CSTC2012jjA0588);Fundamental Research Funds for the Central Universities(Grant No.CQDXWL-2012-123);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120191120032);Sharing Fund of Chongqing University's LargeScale Equipment(Grant No.2010063057,2011063048,2011063049)

摘　　要：Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately causes airway narrowing,thus both structural and functional alterations of airway smooth muscle(ASM)are thought as common final pathway responsible for the bronchial hyperresponsiveness(BHR),the hall mark of asthma.Many chemical and physical factors such as air pollutants,inflammatory agents,mechanical and geometrical properties of the microenvironment could influence structure and/or function of ASM cells.In addition,some re-Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately causes airway narrowing,thus both structural and functional alterations of airway smooth muscle(ASM)are thought as common final pathway responsible for the bronchial hyperresponsiveness(BHR),the hall mark of asthma.Many chemical and physical factors such as air pollutants,inflammatory agents,mechanical and geometrical properties of the microenvironment could influence structure and/or function of ASM cells.In addition,some re-

关 键 词：airway ASTHMA PATHOGENESIS BRONCHIAL REGULATIONS OVALBUMIN alterations contraction ultimately cytometry 

分 类 号：R562.25[医药卫生—呼吸系统]