Change of substrate geometry and laminin density stimulates axon branching  

作　　者：Wenwen Liu Wenfu Zheng Xingyu Jiang 

机构地区：[1]CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology

出　　处：《医用生物力学》2013年第S1期116-117,共2页Journal of Medical Biomechanics

基　　金：financial support is provided by the National Science Foundation of China(50902025, 20890020 and 90813032);the Ministry of Science and Technology of China(2009CB93001 and 2007CB714502);the Chinese Academy of Sciences,and the Human Frontier Science Program

摘　　要：Axon branching enables neurons to contact with multiple targets and respond to their microenvironment.Owing to its importance in neuronal network formation,axon branching has been studied extensively during the past decades.It is reported that ECM(Extra Cellular Matrix)components such as laminin,collagen,and tenascin regulate the morphology and motility of neuronal growth cones in culture,but the effects of their distribution and the change of density on axon branching are not well understood.We fabricated chemically homogeneous substrate by microcontact printing(μCP)and inhomogeneous substrate with different laminin densityAxon branching enables neurons to contact with multiple targets and respond to their microenvironment.Owing to its importance in neuronal network formation,axon branching has been studied extensively during the past decades.It is reported that ECM(Extra Cellular Matrix)components such as laminin,collagen,and tenascin regulate the morphology and motility of neuronal growth cones in culture,but the effects of their distribution and the change of density on axon branching are not well understood.We fabricated chemically homogeneous substrate by microcontact printing(μCP)and inhomogeneous substrate with different laminin density by

关 键 词：LAMININ branching NEURONAL INHOMOGENEOUS chemically understood collagen MOTILITY REGULATE CONES 

分 类 号：R338[医药卫生—人体生理学]