Lubiprostone induced ischemic colitis  

作　　者：Muhammed Sherid Humberto Sifuentes Salih Samo Parakkal Deepak Subbaramiah Sridhar 

机构地区：[1]Department of Internal Medicine,Division of Gastroenterology,Saint Francis Hospital,Evanston,IL 60202,United States [2]Section of Gastroenterology and Hepatology,Medical College of Georgia,Georgia Health Sciences University,Augusta,GA 30912,United States [3]Department of Internal Medicine,Division of Gastroenterology,NorthShore University HealthSystem,Highland Park,IL 60035,United States

出　　处：《World Journal of Gastroenterology》2013年第2期299-303,共5页世界胃肠病学杂志（英文版）

摘　　要：Ischemic colitis accounts for 6%-18% of the causes of acute lower gastrointestinal bleeding.It is often multifactorial and more commonly encountered in the elderly.Several medications have been implicated in the development of colonic ischemia.We report a case of a 54-year old woman who presented with a two-hour history of nausea,vomiting,abdominal pain,and bloody stool.The patient had recently used lubiprostone with close temporal relationship between the increase in the dose and her symptoms of rectal bleeding.The radiologic,colonoscopic and histopathologic findings were all consistent with ischemic colitis.Her condition improved without any serious complications after the cessation of lubiprostone.This is the first reported case of ischemic colitis with a clear relationship with lubiprostone(Naranjo score of 10).Clinical vigilance for ischemic colitis is recommended for patients receiving lubiprostone who are presenting with abdominal pain and rectal bleeding.Ischemic colitis accounts for 6%-18% of the causes of acute lower gastrointestinal bleeding. It is often multifactorial and more commonly encountered in the elderly. Several medications have been implicated in the development of colonic ischemia. We report a case of a 54-year old woman who presented with a two-hour history of nausea, vomiting, abdominal pain, and bloody stool. The patient had recently used lubiprostone with close temporal relationship between the increase in the dose and her symptoms of rectal bleeding. The radiologic, colonoscopic and histopathologic findings were all consistent with ischemic colitis. Her condition improved without any serious complications after the cessation of lubiprostone. This is the first reported case of ischemic colitis with a clear relationship with lubiprostone (Naranjo score of 10). Clinical vigilance for ischemic colitis is recommended for patients receiving lubiprostone who are presenting with abdominal pain and rectal bleeding.

关 键 词：LUBIPROSTONE ISCHEMIC COLITIS Gastrointestinal BLEEDING RECTAL BLEEDING COLONOSCOPY 

分 类 号：R574.62[医药卫生—消化系统]