Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter  

作　　者：Raphael JF Felizardo Niels OS Cmara 

机构地区：[1]Division of Nephrology, Department of Medicine, Federal University of Sao Paulo,Sao Paulo CEP 05508-900, Brazil [2]Department of Immunology, Institute of Biomedical Sciences, University of S o Paulo,Sao Paulo CEP 05508-900, Brazil

出　　处：《World Journal of Gastroenterology》2013年第24期3723-3725,共3页世界胃肠病学杂志（英文版）

摘　　要：Ochratoxin A (OTA) is a secondary metabolite of Asper-gillus and Penicillium, microorganisms that can be haz-ardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular car-cinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. In a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods.Ochratoxin A (OTA) is a secondary metabolite of Asper-gillus and Penicillium, microorganisms that can be haz-ardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular car-cinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. In a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods.

关 键 词：OCHRATOXIN A MYCOTOXIN Food CONTAMINATION HEPATOCELLULAR carcinoma Liver cancer EGYPT 

分 类 号：R735.7[医药卫生—肿瘤]