Properties of Scaffold Reinforcement for Tendon Tissue Engineering in vitro Degradation  

作　　者：龚泽 张佩华 王文祖 罗云蔚 

机构地区：[1]Key Laboratory of Textile Science and Technology,Ministry of Education,Donghua University [2]Colleges of Textiles,Donghua University

出　　处：《Journal of Donghua University(English Edition)》2013年第5期352-355,共4页东华大学学报（英文版）

基　　金：Hi-Tech Research and Development Program of China(863 program)(No.2012AA020507)

摘　　要：Four kinds of braided yarns were produced with different proportions of polyglycolic acid( PGA) and polylactic acid( PLA)multifilaments( 2PGA /1PLA, 2PGA /2PLA, 3PGA /1PLA, and3PGA /2PLA). A novel artificial plain stitch scaffold reinforcement was manufactured by braiding technology and knitting technology respectively. Tendon scaffold reinforcements were investigated for 8weeks in phosphate buffered solution( PBS)( pH = 7. 4) at 37 ℃.The degradation was studied with regard to the mass loss,tensile properties,grams per square meter( g /m2),thickness,caliber,and porosity of scaffold reinforcements. The experimental showed that during the process of 8-week degradation,the mass losses of scaffold reinforcements were small in the first 3-week,but they increased rapidly after 3-week,and the speeds tended to be small gradually after 6-week; the tensile properties dropped rapidly in the first 2-week; the grams per square meter and thicknesses speeded down obviously between 3-week to 6-week. The caliber and porosity of scaffold reinforcements first decreased and then increased gradually. The porosity can reach more than 97%.Four kinds of braided yarns were produced with different proportions of polyglycolic acid( PGA) and polylactic acid( PLA)multifilaments( 2PGA /1PLA, 2PGA /2PLA, 3PGA /1PLA, and3PGA /2PLA). A novel artificial plain stitch scaffold reinforcement was manufactured by braiding technology and knitting technology respectively. Tendon scaffold reinforcements were investigated for 8weeks in phosphate buffered solution( PBS)( pH = 7. 4) at 37 ℃.The degradation was studied with regard to the mass loss,tensile properties,grams per square meter( g /m2),thickness,caliber,and porosity of scaffold reinforcements. The experimental showed that during the process of 8-week degradation,the mass losses of scaffold reinforcements were small in the first 3-week,but they increased rapidly after 3-week,and the speeds tended to be small gradually after 6-week; the tensile properties dropped rapidly in the first 2-week; the grams per square meter and thicknesses speeded down obviously between 3-week to 6-week. The caliber and porosity of scaffold reinforcements first decreased and then increased gradually. The porosity can reach more than 97%.

关 键 词：polyglycolic acid(PGA) polylactic acid(PLA) TENDON SCAFFOLD REINFORCEMENTS degradation in VITRO properties 

分 类 号：TS106.67[轻工技术与工程—纺织工程]