Human induced pluripotent stem cells: A new source for brown and white adipocytes  

作　　者：Anne-Laure Hafner Christian Dani 

机构地区：[1]Faculté de Médecine,UMR CNRS/INSERM,Université Nice Sophia Antipolis,iBV,06107 Nice Cedex 2,France

出　　处：《World Journal of Stem Cells》2014年第4期467-472,共6页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Fondation ARC and ANRS

摘　　要：Mesenchymal stem cells(MSCs) derived from human induced pluripotent stem cells(hiPSCs) provide a novel source for generating adipocytes, thus opening new avenues for fundamental research and clinical medicine. We present the adipogenic potential of hiPSCs and the various methods to derive hiPSC-MSCs. We discuss the main characteristic of hiPSC-MSCs, which is their low adipogenic capacity as compared to adult-MSCs. Finally, we propose several hypotheses to explanation this feature, underlying a potential critical role of the micro-environment. We favour the hypothesis that the range of factors or culture conditions required to induce adipocyte differentiation of MSCs derived from adult tissues and from embryonic-like cells could differ.Mesenchymal stem cells(MSCs) derived from human induced pluripotent stem cells(hiPSCs) provide a novel source for generating adipocytes, thus opening new avenues for fundamental research and clinical medicine. We present the adipogenic potential of hiPSCs and the various methods to derive hiPSC-MSCs. We discuss the main characteristic of hiPSC-MSCs, which is their low adipogenic capacity as compared to adult-MSCs. Finally, we propose several hypotheses to explanation this feature, underlying a potential critical role of the micro-environment. We favour the hypothesis that the range of factors or culture conditions required to induce adipocyte differentiation of MSCs derived from adult tissues and from embryonic-like cells could differ.

关 键 词：Human induced pluripotent STEM CELLS Mesenchymal STEM CELLS BROWN ADIPOCYTES WHITE ADIPOCYTES Obesity LIPODYSTROPHY 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]