Adenoviral short hairpin RNA targeting phosphodiesterase 5 attenuates cardiac remodeling and cardiac dysfunction following myocardial infarction in mice  

作　　者：张健 

机构地区：[1]Affil Zhongshan Hosp,Dalian Univ

出　　处：《China Medical Abstracts(Internal Medicine)》2014年第2期83-83,共1页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To observe the impact of PDE5shRNA on cardiac remodeling and heart function following myocardial infarction in mice.Methods Myocardial infarction(MI)was induced in mice by left coronary artery ligation.Mice were randomly assigned to sham operation group(n=6),PDE5shRNA group(n=12),common adenovirus group(n=15)and DMEM group(n=8).Four weeks post-MI,the survival rate was evaluated.

关 键 词：remodeling HAIRPIN TARGETING RNA LIGATION assigned ADENOVIRUS LVESD staining INFARCT 

分 类 号：R542.22[医药卫生—心血管疾病]