Effect of high glucose and anoxia on Amot expression in vascular endothelial cells with regard to its function in promoting angiogenesis  

作　　者：禇月颉 

机构地区：[1]Dept Diabet Foot,Metab Dis Hosp,Tianjin Med Univ

出　　处：《China Medical Abstracts(Internal Medicine)》2014年第3期151-151,共1页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To observe the effects of high glucose and anoxia on Amot expression in vascular endothelial cells(VECs),and explore its role in angiogenesis.Methods VECs were incubated with different glucose concentrations for 48 h,and then cultured at normal oxygen concentration or anaerobic condition for 24 h.The protein expressions of p130-Amot and p80-Amot were detected by Western blot.After Amot expression was downregulated in VECs by siRNA,wound healing experiments and angiogenesis experiments were performed to test the

关 键 词：ANGIOGENESIS ANAEROBIC INCUBATED HEALING cultured wound promoting centration ATTENUATED migration 

分 类 号：R587.1[医药卫生—内分泌]