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作品数：159被引量：342H指数：9
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Development and application of a nitrogen oxides analyzer based on the cavity attenuated phase shift technique
《Journal of Environmental Sciences》2025年第4期692-703,共12页Jun Zhou Wenjie Wang Yanfeng Wu Chunsheng Zhang Aiming Liu Yixin Hao Xiao-Bing Li Min Shao 
supported by the Natural Science Foundation of Guangdong Province(No.2020A1515110526);the Key-Area Research and Development Programof Guangdong Province(No.2020B1111360003);the National Natural Science Foundation of China(No.42305096).
Nitrogen oxides(NO_(x))are crucial in tropospheric photochemical ozone(O_(3))production and oxidation capacity.Currently,the widely used NO_(x)measurement technique is chemiluminescence(CL)(CL-NO_(x)),which tends to o...
关键词：Nitrogen oxides measurement Cavity attenuated phase shift (CAPS)technique Instrument development O_(3)formation regime O_(x)source 
Down-regulation of SEIPIN transcription attenuated the triacylglycerol accumulation in Nannochloropsis oceanica
《Journal of Oceanology and Limnology》2025年第1期187-195,共9页Lixian LIU Li GUO Hang LIU Xiaohui PAN Yanan ZONG Leili FENG Guanpin YANG 
Supported by the National Key R&D Program of China(No.2022YFF1102300);the Key R&D Program of Shandong Province,China(No.2022LZGC004);the National Natural Science Foundation of China(No.32102757);the Science&Technology Innovation Project of Laoshan Laboratory(No.LSKJ202203205);the Fundamental Research Funds for the Central Universities(No.202262001)。
Abnormal content of protein SEIPIN causes Berardinelli-Seip congenital lipodystrophy type 2(BSCL2)in humans.Previous studies have shown that Arabidopsis thaliana has evolved three SEIPIN homologs,determining the fusio...
关键词：Nannochloropsis oceanica antisense RNA SEIPIN neutral lipid 
Identification of mutations in viral proteins involved in cell adaptation using a reverse genetic system of the live attenuated hepatitis A virus vaccine H2 strain
《Virologica Sinica》2024年第6期882-891,共10页Xiu-Li Yan Jian Li Qing-Qing Ma Hong-Jiang Wang Lin Li Hui Zhao Cheng-Feng Qin Xiao-Feng Li 
funding from the National Key Research and Development Project of China(2021YFC2300202);the National Natural Science Foundation of China(82171820);C.-F.Q.received support from the National Science Fund for Distinguished Young Scholar(81925025);the Innovative Research Group(81621005)from the National Natural Science Foundation China;the Innovation Fund for Medical Sciences(No.2019-I2M-5-049)from the Chinese Academy of Medical Sciences.
The live attenuated hepatitis A virus vaccine H2 strain was developed by passaging a wild-type H2w isolate in cell cultures.Currently,the mechanism underlying its attenuation phenotype remain largely unknown.In this s...
关键词：Hepatitis A virus(HAV) Live attenuated hepatitis A virus vaccine H2 STRAIN Reverse genetics Cell adaptive mutations 
Development of a stable attenuated double-mutant of tobacco mosaic virus for cross-protection
《Journal of Integrative Agriculture》2024年第7期2318-2331,共14页Xiaojie Xu Shaoyan Jiang Chunju Liu Xujie Sun Qing Zhu Xiuzhai Chen Pengchao Jiang Fenglong Wang Yanping Tian Xiangdong Li 
supported by funds from‘Taishan Scholar’Construction Project,China(TS2022-028 and 202101KN275)。
Tobacco(Nicotiana tabacum)and tomato(Solanum lycopersicum)are two major economic crops in China.Tobacco mosaic virus(TMV;genus Tobamovirus)is the most prevalent virus infecting both crops.Currently,some widely cultiva...
关键词：CROSS-PROTECTION double-mutant p126 tobacco mosaic virus VIRULENCE 
Joint deletion of multifunctional MGF505-7R and H240R genes generates a safe and effective African swine fever virus attenuated live vaccine candidate
《Virologica Sinica》2024年第3期355-357,共3页Changjiang Weng Li Huang Guangqiang Ye 
supported by the National Natural Science Foundation of China(grant Nos.U21A20256).
African swine fever(ASF)caused by the ASF virus(ASFV)is a highly contagious disease of pigs and wild boars.Currently,there are no safe,effective commercial vaccines available.The genome of ASFV HLJ/18 contains more th...
关键词：ATTENUATED FEVER SWINE 
A novel live attenuated vaccine candidate protects chickens against subtype B avian metapneumovirus
《Journal of Integrative Agriculture》2024年第5期1658-1670,共13页Lingzhai Meng Mengmeng Yu Suyan Wang Yuntong Chen Yuanling Bao Peng Liu Xiaoyan Feng Tana He Ru Guo Tao Zhang Mingxue Hu Changjun Liu Xiaole Qi Kai Li Li Gao Yanping Zhang Hongyu Cui Yulong Gao 
supported by the National Key Research and Development Program of China (2022YFD1800604);the China Agricultural Research System (CARS-41);the Heilongjiang Touyan Innovation Team Program of China
Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the domi...
关键词：avian metapneumovirus ATTENUATED protection vaccine candidate CHICKENS 
Attenuated retinoic acid signaling is among the early responses in mouse uterus approaching embryo attachment
《Reproductive and Developmental Medicine》2024年第1期61-65,共5页Honglu Diao Shuo Xiao Tong Zhou Taylor E.Martin Wendy T.Watford Xiaoqin Ye 
This study was supported by the grants of NIH R15HD066301,NIH R01HD065939,and NIH R03 HD100652 to X.Y.
The uterus is transiently receptive for embryo implantation.It remains to be understood why the uterus does not reject a semi-allogeneic embryo(to the biological mother)or an allogeneic embryo(to a surrogate)for impla...
关键词：Embryo attachment Pseudo-pregnant uterus Pregnant uterus Natural killer cell activation signature Retinoic acid bioavailability Transmembrane transport and ion transport 
Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants
《Science China(Life Sciences)》2024年第1期83-95,共13页Guangshan Xie Lin Zhu Siwen Liu Cun Li Xin Diao Yanhao Zhang Xiuli Su Yuanyuan Song Guodong Cao Li Zhong Pui Wang Xiaojuan Liu Bobo Wing-Yee Mok Shusheng Zhang Dong-Yan Jin Jie Zhou Honglin Chen Zongwei Cai 
This work was supported by the National Natural Science Foundation of China(21705137);the Theme-based Research Scheme(TRS,T11-709/21-N);the Collaborative Research Fund(CRF,C7042-21G)of the Research Grants Council of the HKSAR government;the Tier 1 Research Start-up Grants from Research Committee of Hong Kong Baptist University(162874).
SARS-CoV-2 continues to threaten human society by generating novel variants via mutation and recombination.The high number of mutations that appeared in emerging variants not only enhanced their immune-escaping abilit...
关键词：SARS-CoV-2 multi-omics attenuated variant predictive pathogenic marker polyamine biosynthesis 
Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector(VSV_(MT))in golden syrian hamster
《Acta Pharmaceutica Sinica B》2023年第12期4856-4874,共19页Yong Ke En Zhang Jianming Guo Xiaoxiao Zhang Lei Wang Duo Chen Xinkui Fang Jianwei Zhu Feng Li Tao Sun Baohong Zhang 
supported by Biomedicine and Technology Supporting Project of Shanghai Science and Technology Innovation Plan(Grant Nos.22S11902200 and 20S11904900,China);Open grant of Engineering Research Center of Cell&Therapeutic Antibody,Ministry of Education,Shanghai Jiao Tong University(Grant No.19X110020009-003,China).
COVID-19 is caused by coronavirus SARS-CoV-2.Current systemic vaccines generally pro-vide limited protection against viral replication and shedding within the airway.Recombinant VSV(rVSV)is an effective vector which i...
关键词：COVID-19 Vesicular stomatitisvirus Matrix protein mutant Mucosal Vaccine Spike protein Variants of concerns Intranasal inoculation Cellular immunity 
Theasinensin A attenuated diabetic development by restoring glucose homeostasis, improving hepatic steatosis and modulating gut microbiota in high-fat-diet/streptozotocin-induced diabetic mice被引量：2
《Food Science and Human Wellness》2023年第6期2073-2086,共14页Weiqi Xu Yujie Huang Wangting Zhou Yujia Peng Xuhui Kan Wei Dong Guijie Chen Xiaoxiong Zeng Zhonghua Liu 
supported by the Key Technology R&D Program of Jiangsu Province(BE2020341);the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Theasinensin A(TSA),a dimer of epigallocatechin gallate,has been preliminarily demonstrated to have hypoglycemia and anti-inflammatory effects.However,little information is available on its potential mechanisms of ant...
关键词：TEA Theasinensin A Diabetes Glucose homeostasis Gut microbiota Hepatic steatosis 
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