Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism  

作　　者：Yumiko Yamashita Takeshi Yabu Michiaki Yamashita 

机构地区：[1]National Research Institute of Fisheries Science [2]Department of Veterinary Medicine,College of Bioresource Sciences,Nihon University

出　　处：《World Journal of Biological Chemistry》2010年第5期144-150,共7页世界生物化学杂志（英文版）（电子版）

基　　金：Supported by In part grants from the Ministry of Agriculture,Forestry,and Fisheries of Japan(Rural Biomass Research Project,BM-D2300)and Fisheries Research Agency

摘　　要：A novel selenium-containing compound,selenoneine,has been isolated as the major form of organic selenium in the blood and tissues of tuna.Selenoneine harbors a selenium atom in the imidazole ring,2-selenylNα,Nα,Nα-trimethyl-L-histidine,and is a selenium analog of ergothioneine.This selenium compound has strong antioxidant capacity and binds to heme proteins,such as hemoglobin and myoglobin,to protect them from iron auto-oxidation,and it reacts with radicals and methylmercury(MeHg) .The organic cations/carnitine transporter OCTN1 transports selenoneine and MeHg,regulates Se-enhanced antioxidant activity,and decreases MeHg toxicity.Thus,the dietary intake of selenoneine,by consuming fish,might decrease the formation of reactive oxygen radicals that could oxidize nucleotides in DNA,and thereby inhibit carcinogenesis,chronic diseases,and aging.A novel selenium-containing compound, selenoneine, has been isolated as the major form of organic selenium in the blood and tissues of tuna. Selenoneine harbors a selenium atom in the imidazole ring, 2-selenyl-Nα, Nα, Nα-trimethyl-L-histidine, and is a selenium analog of ergothioneine. This selenium compound has strong antioxidant capacity and binds to heme proteins, such as hemoglobin and myoglobin, to protect them from iron auto-oxidation, and it reacts with radicals and methylmercury (MeHg). The organic cations/carnitine transporter OCTN1 transports selenoneine and MeHg, regulates Se-enhanced antioxidant activity, and decreases MeHg toxicity. Thus, the dietary intake of selenoneine, by consuming fish, might decrease the formation of reactive oxygen radicals that could oxidize nucleotides in DNA, and thereby inhibit carcinogenesis, chronic diseases, and aging.

关 键 词：Selenium-containing compound ANTIOXIDANT METHYLMERCURY Organic cations/carnitine transporter OCTN1 ERGOTHIONEINE Glutathione peroxidase TUNA Fish 

分 类 号：R151[医药卫生—营养与食品卫生学]