To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient  

作　　者：Andrew Hsu Jen-Fu Lee Daniel E Cramer Menq-Jer Lee 

机构地区：[1]Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48202, United States [2]Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, United States

出　　处：《World Journal of Biological Chemistry》2011年第1期1-13,共13页世界生物化学杂志（英文版）（电子版）

基　　金：Supported by NIH HL071071 (Lee MJ)

摘　　要：Most hematopoietic stem progenitor cells (HSPCs) reside in bone marrow (BM), but a small amount of HSPCs have been found to circulate between BM and tissues through blood and lymph. Several lines of evidence suggest that sphingosine-1-phosphate (S1P) gradient triggers HSPC egression to blood circulation after mobilization from BM stem cell niches. Stem cells also visit certain tissues. After a temporary 36 h short stay in local tissues, HSPCs go to lymph in response to S1P gradient between lymph and tissue and eventually enter the blood circulation. S1P also has a role in the guidance of the primitive HSPCs homing to BM in vivo, as S1P analogue FTY720 treatment can improve HSPC BM homing and engraftment. In stress conditions, various stem cells or progenitor cells can be attracted to local injured tissues and participate in local tissue cell differentiation and tissue rebuilding through modulation the expression level of S1P1, S1P2 or S1P3 receptors. Hence, S1P is important for stem cells circulation in blood system to accomplish its role in body surveillance and injury recovery.Most hematopoietic stem progenitor cells (HSPCs) reside in bone marrow (BM), but a small amount of HSPCs have been found to circulate between BM and tissues through blood and lymph. Several lines of evidence suggest that sphingosine-1-phosphate (S1P) gradient triggers HSPC egression to blood circulation after mobilization from BM stem cell niches. Stem cells also visit certain tissues. After a temporary 36 h short stay in local tissues, HSPCs go to lymph in response to S1P gradient between lymph and tissue and eventually enter the blood circulation. S1P also has a role in the guidance of the primitive HSPCs homing to BM in vivo, as S1P analogue FTY720 treatment can improve HSPC BM homing and engraftment. In stress conditions, various stem cells or progenitor cells can be attracted to local injured tissues and participate in local tissue cell differentiation and tissue rebuilding through modulation the expression level of S1P1, S1P2 or S1P3 receptors. Hence, S1P is important for stem cells circulation in blood system to accomplish its role in body surveillance and injury recovery.

关 键 词：Hematopoietic STEM PROGENITOR cells Tissue specific stem/progenitor cells Mesenchymal STEM CELL STEM CELL homing STEM CELL egress Sphingosine-1-phosphate Sphingosine-1-phosphate GRADIENT Sphingosine-1-phosphate receptors 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]