Yeast nuclear RNA processing  

作　　者：Jade Bernstein Eric A Toth 

机构地区：[1]Department of Biochemistry and Molecular Biology,University of Maryland School of Medicine [2]Marlene and Stewart Greenebaum Cancer Center,University of Maryland School of Medicine

出　　处：《World Journal of Biological Chemistry》2012年第1期7-26,共20页世界生物化学杂志（英文版）（电子版）

基　　金：Supported by The Marlene and Stewart Greenebaum Cancer Center (Toth EA)

摘　　要：Nuclear RNA processing requires dynamic and intricately regulated machinery composed of multiple enzymes and their cofactors.In this review,we summarize recent experiments using Saccharomyces cerevisiae as a model system that have yielded important insights regarding the conversion of pre-RNAs to functional RNAs,and the elimination of aberrant RNAs and unneeded intermediates from the nuclear RNA pool.Much progress has been made recently in describing the 3D structure of many elements of the nuclear degradation machinery and its cofactors.Similarly,the regulatory mechanisms that govern RNA processing are gradually coming into focus.Such advances invariably generate many new questions,which we highlight in this review.Nuclear RNA processing requires dynamic and intricately regulated machinery composed of multiple enzymes and their cofactors. In this review, we summarize recent experiments using Saccharomyces cerevisiae as a model system that have yielded important insights regarding the conversion of pre-RNAs to functional RNAs, and the elimination of aberrant RNAs and unneeded intermediates from the nuclear RNA pool. Much progress has been made recently in describing the 3D structure of many elements of the nuclear degradation machinery and its cofactors. Similarly, the regulatory mechanisms that govern RNA processing are gradually coming into focus. Such advances invariably generate many new questions, which we highlight in this review.

关 键 词：Cryptic unstable transcript Exosome mRNA Mtr4p POLYADENYLATION rRNA SMALL NUCLEAR RNA SMALL NUCLEOLAR RNA TRAMP tRNA 

分 类 号：Q522[生物学—生物化学]