POLYADENYLATION

作品数：22被引量：18H指数：2
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相关领域：生物学更多>>
相关作者：李慧赵国光余鲲涛罗海涛孙亮更多>>
相关机构：中国科学院大学滨州医学院中国科学院吉林大学更多>>
相关期刊：《Genomics, Proteomics & Bioinformatics》《World Journal of Clinical Oncology》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《Molecular Plant》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
《Cellular & Molecular Immunology》2024年第12期1522-1534,共13页Yunzhu Chen Baiwen Chen Jingyu Li Haixin Li Gaoyang Wang Xuemin Cai Qianqian Zhang Xiaoxu Liu Chen Kan Lei Wang Zhengting Wang Hua-Bing Li 
supported by the National Natural Science Foundation of China(No.82325024,82341017,82350112,82030042 and 32070917 to H.-B.L.);the Ministry of Science and Technology of China(No.2021YFA1100800 to H.-B.L.);the Shanghai Municipal Health Commission(No.2022XD047 and 2022JC001 to H.-B.L.).
Macrophage hyperactivation is a hallmark of inflammatory diseases,yet the role of alternative polyadenylation(APA)of mRNAs in regulating innate immunity remains unclear.In this study,we focused on 3’UTR-APA and demon...
关键词：alternative polyadenylation Nudt21 MACROPHAGE AUTOPHAGY INFLAMMATION 
The landscape and clinical relevance of intronic polyadenylation in human cancers
《Journal of Genetics and Genomics》2024年第10期1030-1039,共10页Xiaomeng Cheng Guanghui Jiang Xiaolan Zhou Jing Wang Zhaozhao Zhao Jiayu Zhang Ting Ni 
This work was financially supported by the National Natural Science Foundation of China(92249302,32370592);the National Key Research and Development Program of China(2023YFC3603300,2021YFA0909300).
Intronic polyadenylation(IPA)is an RNA 3'end processing event which has been reported to play important roles in cancer development.However,the comprehensive landscape of IPA events across various cancer types is lack...
关键词：Intronic polyadenylation CANCER Single nucleotide variant Drug sensitivity DATABASE 
Competing endogenous RNAs(ceRNAs)and drug resistance to cancer therapy
《Cancer Drug Resistance》2024年第1期357-381,共25页Kenneth K.W.To Hang Zhang William C.Cho 
support provided by the Chinese University of Hong Kong(Direct Grant 4054782);Guangdong-Hong Kong-Macao New Drug Screening Joint Laboratory(Project 8326200);the SKL Open Fund(SKLOF-X)from the Institute of Chinese Medicine(CUHK).
Competing endogenous RNAs(ceRNAs)are transcripts that possess highly similar microRNA response elements(MREs).microRNAs(miRNAs)are short,endogenous,single-stranded non-coding RNAs(ncRNAs)that can repress gene expressi...
关键词：Alternative mRNA polyadenylation cancer immunotherapy ceRNA crosstalk immune evasion microRNA mRNA 3’untranslated region multidrug resistance non-coding RNA 
RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer被引量：1
《World Journal of Gastrointestinal Oncology》2023年第9期1531-1543,共13页Xue-Jun Wang Yong Liu Bin Ke Li Zhang Han Liang 
BACKGROUND Extensive evidence has illustrated the promotive role of integrin binding sialoprotein(IBSP)in the progression of multiple cancers.However,little is known about the functions of IBSP in gastric cancer(GC)pr...
关键词：Integrin binding sialoprotein Cleavage and polyadenylation factor 6 PYROPTOSIS Gastric cancer 
A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences,Bulk RNA-seq,and Single-cell RNA-seq被引量：1
《Genomics, Proteomics & Bioinformatics》2023年第1期67-83,共17页Wenbin Ye Qiwei Lian Congting Ye Xiaohui Wu 
This work was supported by the National Natural Science Foundation of China(Grant No.61871463 to XW);the Natural Science Foundation of Fujian Province of China(Grant No.2020J01047 to CY).
Alternative polyadenylation(APA)plays important roles in modulating mRNA stability,translation,and subcellular localization,and contributes extensively to shaping eukaryotic transcriptome complexity and proteome diver...
关键词：POLYADENYLATION Predictive modeling RNA-SEQ scRNA-seq Machine learning 
mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases被引量：2
《Genes & Diseases》2023年第1期165-174,共10页Siyao Guo Shuibin Lin 
This research was supported by grants from National Natural Science Foundation of China(No.81922052,81974435,81772999);the Natural Science Foundation of Guangdong Province,China(No.2019B151502011);the Guangzhou People's Livelihood Science and Technology Project,China(No.201903010006).
The mRNA polyadenylation plays essential function in regulation of mRNA metabolism.Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression.Under the action o...
关键词：Alternative polyadenylation(APA) Cancer Gene expression mRNA polyadenylation POLY(A) 
DeeReCT-APA:Prediction of Alternative Polyadenylation Site Usage Through Deep Learning
《Genomics, Proteomics & Bioinformatics》2022年第3期483-495,共13页Zhongxiao Li Yisheng Li Bin Zhang Yu Li Yongkang Long Juexiao Zhou Xudong Zou Min Zhang Yuhui Hu Wei Chen Xin Gao 
supported by the King Abdullah University of Science and Technology(KAUST)Office of Sponsored Research(OSR)(Grant Nos.URF/1/4098-01-01,BAS/1/1624-01,FCC/1/1976-18-01,FCC/1/1976-23-01,FCC/1/1976-25-01,FCC/1/1976-26-01,and FCS/1/4102-02-01);the International Cooperation Research Grant from Science and Technology Innovation Commission of Shenzhen Municipal Government,China(Grant No.GJHZ20170310161947503 to YH);the Shenzhen Science and Technology Program,China(Grant No.KQTD20180411143432337 to YH and WC).
Alternative polyadenylation(APA)is a crucial step in post-transcriptional regulation.Previous bioinformatic studies have mainly focused on the recognition of polyadenylation sites(PASs)in a given genomic sequence,whic...
关键词：POLYADENYLATION Gene regulation Sequence analysis Deep learning BIOINFORMATICS 
How to make the end of a gene,the simple way
《BIOCELL》2022年第6期1453-1457,共5页KAREL H.M.VAN WELY 
The author is financed in part by the Spanish Government(Ministerio de Ciencia e Innovación,Grant MCIN/AEI PID2019-110574RB-I00).
Transcription termination of nearly all protein-coding genes in mammals requires 3’end processing by a multiprotein complex that will cleave and polyadenylate the messenger RNA precursor.Because a variety of enzyme c...
关键词：RNA transcription RNA polymerase II pausing SPLICING TERMINATION POLYADENYLATION 
Alternative polyadenylation:An untapped source for prostate cancer biomarkers and therapeutic targets?
《Asian Journal of Urology》2021年第4期407-415,共9页Akira Kurozumi Shawn E.Lupold 
The authors would like to acknowledge funding from the Department of Defense Prostate Cancer Research Program W81XWH-17-1-0581 and W81XWH-19-1-0450;Shawn EL,the National Cancer Institute P30CA006973;William G.Nelson,and The Patrick C.Walsh Cancer Research Fund to Shawn EL,for support of this work.
Objective:To review alternative polyadenylation(APA)as a mechanism of gene regulation and consider potential roles for APA in prostate cancer(PCa)biology and treatment.Methods:An extensive review of mRNA polyadenylati...
关键词：Prostate cancer POLYADENYLATION Alternative polyadenylation 30-untranslated region MICRORNA Intronic polyadenylation 
OsEDM2L mediates m^(6)A of EAT1 transcript for proper alternative splicing and polyadenylation regulating rice tapetal degradation被引量：1
《Journal of Integrative Plant Biology》2021年第11期1982-1994,共13页Kun Ma Jingluan Han Zixu Zhang Heying Li Yanchang Zhao Qinlong Zhu Yongyao Xie Yao‐Guang Liu Letian Chen 
This work was funded by National Natural Science Foundation of China(32001519,32030080);The Major Program of Guangdong Basic and Applied Research(2019B030302006);China Postdoctoral Science Fund(2020M672653)。
N^(6)-methyladenosine(m^(6)A) modification affects the post-transcriptional regulation of eukaryotic gene expression, but the underlying mechanisms and their effects in plants remain largely unknown. Here,we report th...
关键词：alternative polyadenylation(APA) alternative splicing(AS) N^(6)-methyladenosine(m^(6)A) programmed cell death(PCD) 
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