The landscape and clinical relevance of intronic polyadenylation in human cancers  

作　　者：Xiaomeng Cheng Guanghui Jiang Xiaolan Zhou Jing Wang Zhaozhao Zhao Jiayu Zhang Ting Ni 

机构地区：[1]State Key Laboratory of Genetic Engineering,National Clinical Research Center for Aging and Medicine,Huashan Hospital,Collaborative Innovation Center of Genetics and Development,Human Phenome Institute,Center for Evolutionary Biology,Shanghai Engineering Research Center of Industrial Microorganisms,School of Life Sciences,Fudan University,Shanghai 200438,China [2]MOE Key Laboratory of Contemporary Anthropology,School of Life Sciences,Fudan University,Shanghai 200438,China [3]State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock,Insttutes of Biomedical Sciences,School of Life Sciences,Inner Mongolia University,Hohhot,Inner Mongolia 010070,China

出　　处：《Journal of Genetics and Genomics》2024年第10期1030-1039,共10页遗传学报（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(92249302,32370592);the National Key Research and Development Program of China(2023YFC3603300,2021YFA0909300).

摘　　要：Intronic polyadenylation(IPA)is an RNA 3'end processing event which has been reported to play important roles in cancer development.However,the comprehensive landscape of IPA events across various cancer types is lacking.Here,we apply IPAFinder to identify and quantify IPA events in 10,383 samples covering all 33 cancer types from The Cancer Genome Atlas(TCGA)project.We identify a total of 21,835 IPA events,almost half of which are ubiquitously expressed.We identify 2761 unique dynamically changed IPA events across cancer types.Furthermore,we observe 8855 non-redundant clinically relevant IPA events,which could potentially be used as prognostic indicators.Our analysis also reveals that dynamic IPA usage within cancer signaling pathways may affect drug response.Finally,we develop a user-friendly data portal,IPACancer Atlas(http://www.tingni-lab.com/Pancan_IPA),to search and explore IPAs in cancer.

关 键 词：Intronic polyadenylation CANCER Single nucleotide variant Drug sensitivity DATABASE 

分 类 号：R730.2[医药卫生—肿瘤]