POLY(A)

作品数：70被引量：168H指数：4
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相关机构：南京农业大学山东农业大学厦门大学中国科学院遗传与发育生物学研究所更多>>
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Direct RNA sequencing in plants:Practical applications and future perspectives
《Plant Communications》2024年第11期54-71,共18页Xi-Tong Zhu Pablo Sanz-Jimenez Xiao-Tong Ning Muhammad Tahir ul Qamar Ling-Ling Chen 
Guangxi Natural Science Foundation(2024GXNSFGA010003);National Natural Science Foundation of China(32270712 and 31871269);Guangxi Science and Technology Major Program(AA23062085).
The transcriptome serves as a bridge that links genomic variation to phenotypic diversity.A vast number of studies using next-generation RNA sequencing(RNA-seq)over the last 2 decades have emphasized the essential rol...
关键词：direct RNA sequencing novel isoforms fusion transcripts poly(A)tail RNA modifications 
The non-canonical poly(A)polymerase FAM46C promotes erythropoiesis
《Journal of Genetics and Genomics》2024年第6期594-607,共14页Ke Yang Tiangi Zhu Jiaying Yin Qiaoli Zhangg Jing Li Hong Fan Gajing Han Weiyin Xu Nan Liu Xiang Lv 
funded by the Starting Fund from Zhejiang University to N.L.and grants to X.L.from National Natural Science Foundation of China(82170120 and 81670108);CAMS Initiative for Innovative Medicine(2017-12M-B&R-04);Medical Epigenetics Research Cen-ter,CAMS(2018PT31015);the State Key Laboratory of Medical Molecular Biology(2060204);Haihe L aboratory of Cell Ecosystem Innovation Fund(22HHXBSS00008).
The post-transcriptional regulation of mRNA is a crucial component of gene expression.The disruption of this process has detrimental effects on the normal development and gives rise to various diseases.Searching for n...
关键词：FAM46C TENT5C Poly(A)polymerase ERYTHROBLASTS Post-transcriptional regulation Erythroid-specific enhancer 
Poly(A)-specific RNase(PARN)generates and regulates miR-125a-5p 3’-isoforms,displaying an altered expression in breast cancer被引量：2
《Signal Transduction and Targeted Therapy》2024年第5期1805-1807,共3页Luisa Tomasello Shoshanah M.Holub Giovanni Nigita Rosario Distefano Carlo M.Croce 
The authors thank the Genomics Shared Resource at The Ohio State University Comprehensive Cancer Center(OSU CCC),Columbus,OH.This work was supported by the NCI(NIH)grant R35CA197706 to C.M.Croce.
Dear Editor,MicroRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing ...
关键词：BREAST cancer advancement 
An engineered surrogate poly(A)tail to wag translation initiation
《Cell Research》2024年第2期95-96,共2页Stefan Lohse Wilfried Weber 
A novel approach for controlling translation initiation in mammalian cells is demonstrated based on the conditional attachment of eukaryotic translation initiation factor-binding proteins to the 3′UTR of mRNAs via sm...
关键词：TRANSLATION OVERCOME LIMITATIONS 
Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells
《Cell Research》2024年第1期31-46,共16页Jiawei Shao Shichao Li Xinyuan Qiu Jian Jiang Lihang Zhang Pengli Wang Yaqing Si Yuhang Wu Minghui He Qiqi Xiong Liuqi Zhao Yilin Li Yuxuan Fan Mirta Viviani Yu Fu Chaohua Wu Ting Gao Lingyun Zhu Martin Fussenegger Hui Wang Mingqi Xie 
supported by the HRHI program 202209009 of Westlake Laboratory of Life Sciences and Biomedicine,Westlake Education Foundation,Tencent Foundation,the National Natural Science Foundation of China(32071429);the Ministry of Science and Technology of China(2020YFA0909200);supported by China Postdoctoral Science Foundation(2020M671805,2020T130107ZX to J.S.).Some drawings in this manuscript were kindly provided by Scidraw.io.
Here,we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation.By excising the natural poly-adenylation(poly-A)signal of target genes and replacing it with a syntheti...
关键词：TRANSLATIONAL RENDER alone 
Poly(A)-specific ribonuclease protein promotes the proliferation,invasion and migration of esophageal cancer cells
《World Journal of Gastroenterology》2023年第31期4783-4796,共14页Fu-Wei Zhang Xiao-Wei Xie Meng-Hua Chen Jian Tong Qun-Qing Chen Jing Feng Feng-Ti Chen Wen-Qi Liu 
BACKGROUND Bioinformatics analysis showed that the expression of the poly(A)-specific ribonuclease(PARN)gene in gastric cancer,head and neck squamous cell carcinoma,melanoma,cervical cancer and lung squamous cell carc...
关键词：Poly(A)-specific ribonuclease Esophageal cancer APOPTOTIC Phosphatidylinositol 3-kinase/protein kinase B 
哺乳动物卵子与早期胚胎中全转录组poly(A)尾研究进展
《遗传》2023年第4期273-278,共6页王文龙 张春霞 
在哺乳动物卵子向胚胎转变过程中,卵子和胚胎中的转录在合子基因组激活之前都是沉默的,因此mRNA转录后修饰在此过程发挥着重要的作用。poly(A)尾巴是影响mRNA命运和翻译效率的一种重要的转录后修饰。随着测序技术和分析工具的进步,尤其...
关键词：poly(A)尾 PAIso-seq 早期胚胎发育 卵子向胚胎转变 
m^(6)A-modified RNAs possess distinct poly(A)tails被引量：1
《Journal of Genetics and Genomics》2023年第3期208-211,共4页Shuang Wu Yiwei Zhang Lan Yao Jiaqiang Wang Falong Lu Yusheng Liu 
supported by the National Key Research and Development Program of China(2020YFA0804000);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA24020203);the CAS Project for Young Scientists in Basic Research(YSBR-012);the National Natural Science Foundation of China(31970588,32170606,32201060);the Natural Science Foundation of Heilongjiang province(YQ2020C003);the China Postdoctoral Science Foundation(2020M670516,2020T130687);the State Key Laboratory of Molecular Developmental Biology。
N^(6)-methyladenosine(m^(6)A)has been found to be the most common type of post-transcriptional chemical modification in mammalian mRNAs and long non-coding RNAs(lncRNAs)(Dominissini et al.,2012;Meyer et al.,2012).In b...
关键词：N^(6)-methyladenosine(m^(6)A) preferentially 
GRSF1在小鼠脑缺血再灌注损伤中的作用:与铁死亡的关系
《中华麻醉学杂志》2023年第3期354-358,共5页李亚男 李冰玉 王苏 刘恋 夏中元 赵博 
国家自然科学基金(82102295,81901994)。
目的评价富含鸟嘌呤序列的结合因子1(GRSF1)在小鼠脑缺血再灌注损伤中的作用及其与铁死亡的关系。方法清洁级雄性C57BL/6小鼠24只,8~10周龄,体质量20~25 g,采用随机数字表法分为4组(n=6):假手术组(Sham组)、脑缺血再灌注组(IR组)、脑缺...
关键词：Poly(A)结合蛋白质类 铁死亡 脑 再灌注损伤 
mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases被引量：2
《Genes & Diseases》2023年第1期165-174,共10页Siyao Guo Shuibin Lin 
This research was supported by grants from National Natural Science Foundation of China(No.81922052,81974435,81772999);the Natural Science Foundation of Guangdong Province,China(No.2019B151502011);the Guangzhou People's Livelihood Science and Technology Project,China(No.201903010006).
The mRNA polyadenylation plays essential function in regulation of mRNA metabolism.Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression.Under the action o...
关键词：Alternative polyadenylation(APA) Cancer Gene expression mRNA polyadenylation POLY(A) 
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