Poly(A)-specific RNase(PARN)generates and regulates miR-125a-5p 3’-isoforms,displaying an altered expression in breast cancer  

作　　者：Luisa Tomasello Shoshanah M.Holub Giovanni Nigita Rosario Distefano Carlo M.Croce 

机构地区：[1]Department of Cancer Biology and Genetics,The Ohio State University,Columbus,OH,USA [2]Department of Internal Medicine,Division of Hematology,The Ohio State University,Columbus,OH,USA

出　　处：《Signal Transduction and Targeted Therapy》2024年第5期1805-1807,共3页信号转导与靶向治疗（英文）

基　　金：The authors thank the Genomics Shared Resource at The Ohio State University Comprehensive Cancer Center(OSU CCC),Columbus,OH.This work was supported by the NCI(NIH)grant R35CA197706 to C.M.Croce.

摘　　要：Dear Editor,MicroRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing highlighted the existence of miRNA isoforms(isomiRs)resulting from alternative processing,RNA editing,or post-transcriptional modifications.

关 键 词：BREAST cancer advancement 

分 类 号：R730[医药卫生—肿瘤]