An engineered surrogate poly(A)tail to wag translation initiation  

作　　者：Stefan Lohse Wilfried Weber 

机构地区：[1]INM-Leibniz Institute for New Materials,Campus D22,66123,Saarbrücken,Germany [2]Department of Materials Science and Engineering,Saarland University,Campus D22,66123,Saarbrücken,Germany [3]CIBSS-Centre for Integrative Biological Signalling Studies,University of Freiburg,Schänzlestr.18,79104,Freiburg,Germany

出　　处：《Cell Research》2024年第2期95-96,共2页细胞研究（英文版）

摘　　要：A novel approach for controlling translation initiation in mammalian cells is demonstrated based on the conditional attachment of eukaryotic translation initiation factor-binding proteins to the 3′UTR of mRNAs via small molecule-,light-,or protein-responsive interactions.The technology overcomes limitations of previously used transcription-based switches and was shown to be functional in managing diabetes or tumor growth in preclinical animal models.

关 键 词：TRANSLATION OVERCOME LIMITATIONS 

分 类 号：Q753[生物学—分子生物学]