NUCLEOLAR

作品数：36被引量：36H指数：3
导出分析报告
相关领域：生物学医药卫生更多>>
相关作者：焦明大郝水宋朝霞曾宪录王晓光更多>>
相关机构：东北师范大学长春师范学院北京大学秦皇岛市海港医院更多>>
相关期刊：《Chinese Medical Journal》《Science China(Life Sciences)》《World Journal of Hematology》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
PPAN modulates mouse male germ cell development via maintaining nucleolar homeostasis
《Genes & Diseases》2025年第1期25-28,共4页Yu Tian Yufan Wang Qing Tian Guiping Cheng Li-quan Zhou 
supported by the National Natural Science Foundation of China(No.NSFC 32170820);the National Key R&D Program of China(No.2022YFC2702704);the Program for HUST Academic Frontier Youth Team.
In mammalian cells,the nucleolus serves as a factory for organizing ribosomal RNA(rRNA)synthesis and ribosomal biogenesis.Moreover,by interacting with rRNA genes and heterochromatin,nucleolus also functions in chromat...
关键词：RRNA HOMEOSTASIS IMPLANTATION 
AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis
《Science China(Life Sciences)》2025年第1期204-218,共15页Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou 
supported by the National Natural Science Foundation of China(82173022,82072879,82273098);the Innovative Research Team of High-level Local University in Shanghai.
Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies,including WEE1 inhibition.Considering that p53 activation can also lead to multiple types...
关键词：P53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress 
过表达NOLC1诱导人非小细胞肺癌细胞凋亡
《微生物学杂志》2024年第2期87-96,共10页杜亚兰 张茂盛 王旌羽 张璐燕 周常博 佘晓双 郑方亮 朱春玉 
辽宁省教育厅一般项目(LJC201910);辽宁省教育厅服务地方项目(LJKFZ20220179)。
人核仁磷酸化蛋白1(Nucleolar and coiledbody phosphoprotein 1,NOLC1)在癌症的发生发展过程中起着至关重要的调控作用,为探讨NOLC1对肺癌细胞的作用,本研究通过Gateway系统构建重组NOLC1腺病毒载体,成功包装NOLC1腺病毒后,分别感染正...
关键词：NOLC1(Nucleolar and coiledbody phosphoprotein 1) 肺癌细胞 腺病毒载体 过表达 细胞凋亡 
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth被引量：1
《Science China(Life Sciences)》2023年第11期2684-2687,共4页Hanzhi Dong Quan Liao Bangxiang Xie Yu-an Qiu Zhiqiang Peng Jun Deng Jianping Xiong Hua Lu Qian Hao Xiang Zhou 
supported by the National Natural Science Foundation of China(82072879,82273098,81874053,82173022);General Program of Open Science Foundation of Jiangxi Cancer Hospital(2021J04);HL was in part funded by the Reynolds and Ryan Families Chair fund in Transitional Cancer at Tulane.
Dear Editor,Ferroptosis is a non-apoptotic form of regulated cell death driven by iron-dependent phospholipid peroxidation(Chen et al.,2021).The tumor suppressor p53 promotes ferroptosis by increasing lipid peroxidati...
关键词：DEATH p53 PLA2 
The Phytophthora nucleolar effector Pi23226 targets host ribosome biogenesis to induce necrotrophic cell death
《Plant Communications》2023年第5期263-276,共14页Soeui Lee Jaehwan Kim Myung-Shin Kim Cheol Woo Min Sun Tae Kim Sang-Bong Choi Joo Hyun Lee Doil Choi 
supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(NRF-2018R1A5A1023599[SRC],NRF-2021R1A2B5B03001613,and NRF-2019R1C1C1008698).
Pathogen effectors target diverse subcellular organelles to manipulate the plant immune system.Although the nucleolus has emerged as a stress marker and several effectors are localized in the nucleolus,the roles of nu...
关键词：Phytophthora infestans hemibiotroph nucleolar effector cell death ribosome biogenesis translation inhibition 
Carrimycin,a first in-class anti-cancer agent,targets selenoprotein H to induce nucleolar oxidative stress and inhibit ribosome biogenesis被引量：1
《Cancer Pathogenesis and Therapy》2023年第2期111-115,共5页LaYow C.Yu Danielle D.Dang Sophie Zhuang Shuran Chen Zhengping Zhuang Jared S.Rosenblum 
supported in part by the Intramural Program of the NCI and NINDS(National Institutes of Health)and did not receive any specific grant from funding agencies(e.g.,public,commercial,or not-forprofit sectors)outside of the authors'academic institution.
Carrimycin is a synthetic macrolide antibiotic that has been shown to have anti-cancer activity;however,its exact mechanism of action and molecular target were previously unknown.It was recently elucidated that Isoval...
关键词：SELENOPROTEIN Ribosome biogenesis MACROLIDE Cancer Carrimycin 
Commentary to“Carrimycin,a first in-class anti-cancer agent,targets selenoprotein H to induce nucleolar oxidative stress and inhibit ribosomal biogenesis”
《Cancer Pathogenesis and Therapy》2023年第2期157-158,共2页Peng Lyu 
On January 2,2023,Cancer Pathogenesis and Therapy(CPT)published an online article entitled“Carrimycin as an anticancer candidate inhibits tumors by targeting selenoprotein H in the nucleus of tumor cells to induce nu...
关键词：expression. al. Cancer 
Nucleolar URB1 ensures 3'ETS rRNA removal to prevent exosome surveillance
《四川生理科学杂志》2023年第3期530-530,共1页Lin Shan 
The nucleolus is the most prominent membraneless condensate in the nucleus.It comprises hundreds of proteins with distinct roles in the rapid transcription of ribosomal RNA(rRNA)and efficient processing within units c...
关键词：RRNA hundreds PRECISE 
LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells被引量：6
《Protein & Cell》2022年第7期490-512,共23页Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang 
We thank Hengyu Fan,Dan Zhang,Jianzhong Sheng,Pengfei Xu and Hua Lu for discussing and sharing facilities.J.Z.is supported by the National Key Research and Development Program of China(2018YFA0107100,2018YFA0107103,2018YFC1005002);the National Natural Science Foundation projects of China(31871453,91857116);the Zhejiang Natural Science Foundation projects of China(LR19C120001);High-Performance Computing Platform in Center of Cryo-Electron Microscopy of Zhejiang University and core facilities,Zhejiang University School of Medicine.H.Y.is supported by the Zhejiang Natural Science Foundation Projects of China(Grant No.LQ21C120002);J.W.is supported by National Institutes of Health(HD097268);New York State Stem Cell Science(C32569GG).
LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol wh...
关键词：LIN28 2-cell-like program nucleolar integrity NCL/TRIM28 complex 
PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia被引量：2
《Acta Pharmaceutica Sinica B》2022年第4期1913-1927,共15页Hsiang-i Tsai Yanping Wu Rui Huang Dandan Su Yingyi Wu Xiaoyan Liu Linglu Wang Zhanxue Xu Yuxin Pang Chong Sun Chao He Fan Shu Haitao Zhu Dongqing Wang Fang Cheng Laiqiang Huang Hongbo Chen 
supported by the National Natural Science Foundation of China (81702750, 81670141, 81970145and 82001698);Natural Science Foundation of Guangdong Province (2020A1515011465and 2020A151501467, China);Science, Technology & Innovation Commission of Shenzhen Municipality ( JCYJ20180307154700308, JCYJ20170818163844015, JCYJ20180307151420045, JCYJ20190807151609464, JCYJ20200109142605909 and JCYJ20210324120007020, China);Sun Yat-sen University (20ykzd17 and 20ykpy122, China);International Collaboration of Science and Technology of Guangdong Province (2020A0505100031, China);Guangdong Provincial Key Laboratory of Digestive Cancer Research (No.2021B1212040006,China);The Social Development Foundation of Jiangsu Province (BE2018691, China);Sigrid Jusélius foundation in Finland for funding the project (Finland)
Mutations in the plant homeodomain-like finger protein 6(PHF6)gene are strongly associated with acute myeloid(AML)and T-cell acute lymphoblastic leukemia(T-ALL).In this study,we demonstrated that PHF6 can bind to H3K9...
关键词：PHF6 SUV39H1 AML rDNA transcription EPIGENETIC CX5461 METHYLTRANSFERASE LEUKEMIA 
全选清除导出
共4页<1234>
检索报告 对象比较 聚类工具 使用帮助 返回顶部