Does a melatonin supplement alter the course of gastroesophageal reflux disease?  

作　　者：Mariusz H Madalinski 

机构地区：[1]NHS Lothian-University Hospitals Division,Edinburgh EH1 4SA,United Kingdom [2]Department of Gastroenterology,Western General Hospital,Crewe Road South,Edinburgh EH4 2XU,United Kingdom

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2011年第6期50-51,共2页世界胃肠药理与治疗学杂志（英文版）（电子版）

摘　　要：Symptomatic gastro-esophageal reflux disease(GERD) is a very common disease.The consequence of GERD is not only erosive esophagitis,but also esophageal stricture,Barrett's esophagus and extra-esophageal damage(including the lungs,throat,sinuses,middle ear and teeth).GERD and Barrett's esophagus are also identif ied as major risk factors for esophageal carcinoma.Therapy with melatonin prevents esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals,then further studies are required in humans to establish whether a melatonin supplement is able to protect the patients with GERD from erosions,Barrett's and neoplasia.Symptomatic gastro-esophageal reflux disease (GERD) is a very common disease. The consequence of GERD is not only erosive esophagitis, but also esophageal stricture, Barretts esophagus and extra-esophageal damage (including the lungs, throat, sinuses, middle ear and teeth). GERD and Barretts esophagus are also identified as major risk factors for esophageal carcinoma. Therapy with melatonin prevents esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals, then further studies are required in humans to establish whether a melatonin supplement is able to protect the patients with GERD from erosions, Barretts and neoplasia.

关 键 词：Gastro-esophageal REFLUX disease MELATONIN CHEMOPROTECTION Barrett’s 

分 类 号：R571[医药卫生—消化系统]