Aurora-A激酶及其抑制剂研究进展  

The research progress of a Aurora-A kinase and its inhibitors

作　　者：许晓辉 孙陶利[2] 朱玉婷[3] 

机构地区：[1]平凉市药品检验检测中心,甘肃平凉744000 [2]湘南学院基础医学部,湖南郴州423000 [3]汉中市人民医院药剂科,陕西汉中723000

出　　处：《转化医学杂志》2014年第2期79-83,共5页Translational Medicine Journal

摘　　要：Aurora-A是Aurora激酶家族中的重要成员之一,在细胞有丝分裂过程中发挥着重要功能,Aurora-A的过度表达与人类多种恶性肿瘤紧密相关。鉴于Aurora-A的重要作用,其被作为一个设计抗肿瘤药物的新靶点。目前已有几种选择性Aurora-A激酶抑制剂进入到临床研究中,并且表现出良好的治疗效果。本文从Aurora-A激酶的生物学、与肿瘤的密切关系及其抑制剂的研发状况进行综述。Aurora-A is an important member of Aurora kinase family,which plays a signifi-cant function in cell mitosis process.The overexpression of Aurora-A is closely associated with a va-riety of human tumors.Aurora-A is designed as a new target for anticancer drugs,owing to its major function in cell mitosis.At present,a few selective inhibitors of Aurora-A kinase have entered the clinical study and showed good therapeutic effect.In this article,we will state the biological proper-ties of Aurora-A kinase.At the same time,we will introduce the close relationship between Aurora-A kinase and tumor,and further outline the development status of Aurora-A kinase inhibitors.

关 键 词：AURORA-A 有丝分裂 抗肿瘤 激酶抑制剂 

分 类 号：R346[医药卫生—基础医学]