脑血流率在脑胶质瘤分级诊断中的应用  

Relative cerebral blood flow in evaluating the histopathologic grade of cerebral gliomas

作　　者：武洪林[1] 陈君坤[1] 张宗军[1] 黄伟[1] 卢光明[1] 李林[1] 

机构地区：[1]南京大学医学院临床学院,南京军区南京总医院医学影像科,南京210002

出　　处：《放射学实践》2004年第6期392-394,共3页Radiologic Practice

摘　　要：目的 :评价相对脑血流率 (rCBF)在脑胶质类肿瘤病理分级中的价值。方法 :对 18例脑胶质类肿瘤患者术前行MR灌注成像 ,序列采用GRE EPI ,经去卷积法及运用AIF后获得相对脑血容量 (rCBV )、rCBF图。计算出最大rCBV、rCBF后 ,与病理学分级进行对照分析。结果 :高、低度恶性胶质类肿瘤的rCBV值分别为 6.19、1.76,rCBF值分别为 6.5 8、1.62 ,高、低度恶性胶质类肿瘤之间的rCBV或rCBF值差异均有显著性意义 (t检验 ,P <0 .0 1)。另外 ,rCBV、rCBF间有高度相关性 (r =0 .911,P <0 .0 1)。结论 :除rCBV外 。Objective:To assess the value of rCBF in assessing the histophathologic grade of cerebral gliomas. Methods: 18 patients with proven cerebral gliomas were studied preoperatively, using a first pass Gd DTPA T 2 weighted echoplanar perfusion sequence. The perfusion data were deconvoluted, with an arterial input function(AIF),to obtain a color map of rCBV and rCBF. The student t test was used to determine if there was a statistical difference between the mean values of rCBV or rCBF in high grade gliomas and in low grade gliomas. Results: The mean of the rCBV was 6.19 in the high grade gliomas and 1.76 in the low grade gliomas. The mean of the rCBF was 6.58 in the high grade gliomas and 1.62 in the low grade gliomas.A significant difference in each rCBV and rCBF was found between the high and low grade gliomas ( t test, P <0.01).Additionally, there was a strong correlation between the rCBV and rCBF ( r =0.911; P < 0.01). Conclusion:A rCBF, besides a rCBV, can be a useful tool in the evaluation of the histopathologic grade of cerebral gliomas.

关 键 词：脑胶质瘤 血流动力学 脑血容量 CBV 脑血流率 CBF MR灌注成像 肿瘤分级诊断 

分 类 号：R739.4[医药卫生—肿瘤]