广东鼻咽癌高危家族成员发病危险性的流行病学研究  

Epidemiological Study of Nasopharyngeal Carcinoma Risk in Relatives of High risk Families in Guangdong

作　　者：贾卫华[1] 许宗利[2] 冯炳健[1] 黄丽惜[1] 余杏娟[1] 冯启胜[1] 张锋[3] 曾益新[1] 

机构地区：[1]中山大学肿瘤防治中心实验研究部,广东广州510060 [2]中山大学公共卫生学院卫生统计教研室,广东广州510080 [3]中山大学肿瘤防治中心鼻咽癌科,广东广州510060

出　　处：《癌症》2004年第7期767-770,共4页Chinese Journal of Cancer

基　　金：国家自然科学基金(No.30000141);国家科技攻关项目(No.2002BA711A03)~~

摘　　要：背景与目的鼻咽癌具有家族聚集现象,目前相关的研究多局限于高发家系报告或小样本量的病例对照研究。鼻咽癌高危人群中的高危家族成员发病风险性到底有多高,目前还没有一个量化的指标衡量。本研究在高发区广东进行大样本高发家系收集的基础上,对其家族成员鼻咽癌发病风险性进行定量估算,为遗传流行病学研究及临床遗传咨询提供资料。方法在中山大学肿瘤防治中心共收集广东籍鼻咽癌高发家系113个,使用标化发病比(SIR)进行一级亲属发病危险性的估算。结果鼻咽癌高发家系中一级亲属的SIR值为37.55,其中,兄弟、姐妹、父亲、母亲的SIR值分别为50.72、79.64、7.12和33.58。结论鼻咽癌高危家族成员的发病危险性是一般人群的7.12倍至79.64倍。BACKGROUND & OBJECTIVE: Familial clustering of NPC has been widely observed, however, related investigations were mainly involved in individual reports for high risk families or case control study with small sample size, so no quantitive evaluation for NPC risk in relatives of high risk families documented in high risk area until now. The purpose of the study was to estimate NPC risk among relatives of high risk pedigrees in Guangong province, so as to provide information for genetic epidemiology and clinical genetic consultation. METHODS:One hundred and thirteen high risk pedigrees were collected in the Cancer Center of Sun Yat sen University, and standardized incidence ratio (SIR) was used to estimate NPC risk of first degree relatives(FDR). RESULTS: NPC risk was significantly higher in first degree relatives that in general population, and SIR was 37.55; in addition, SIRs were 50.72,79.64,7.12, and 33.58 in their brothers, sisters, fathers, and mothers respectively. CONCLUSION:NPC risk of relatives in familial NPC pedigrees elevates 7.12 to 79.64 times in high risk families.

关 键 词：鼻咽肿瘤 遗传易感性 先证者 标化发病比 

分 类 号：R739.63[医药卫生—肿瘤]