脑缺血再灌流后多胺与兴奋性氨基酸的释放  

The release of polyamines and excitatory amino acid during cerebral ischemia and reperfusion

作　　者：郑彩梅[1] 黎红华[1] 吕智勇[1] 

机构地区：[1]第三军医大学西南医院神经内科,630038

出　　处：《第三军医大学学报》1993年第4期340-343,共4页Journal of Third Military Medical University

摘　　要：本实验观察全脑缺血大鼠缺血期与再灌流期海马组织多胺与EAA的含量变化,结果发现再灌流期腐胺含量增高,EAA释放增加,采用EAA的NMDA受体拮抗剂MK-801可使增高的腐胺降低,表明多胺代谢紊乱与EAA释放密切相关,多胺代谢又受MNDA受体的调节,多胺与EAA在缺血性脑损伤中共同起着重要的作用。The dynamic changes of the contents of polyamines and excitatory amino acid in the hippocampus during cerebral ischemia and reperfusion were observed in rats.It was found that the content of putrescine was increased and the release of excitatory amino acid elevated during reperfusion,and the increase of putrescine could be stopped when the antagonist of NM-DA receptor of excitatory amino acid,that is,MK-801,was administered.These facts suggest that the metabolic disturbance of polyamines in closely related to the release of excitatory amino acid and modulated by NMDA receptors.The combination of polyamines with excitatory amino acid may play an important role in the ischemic damage of the brain.

关 键 词：氨基酸 再灌注损伤 多胺 脑缺血 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]