非甾体抗炎药(NSAIDs)的新进展  

The New Development of the Non-steroid Anti-inflammatory Drugs (NSAIDs)

作　　者：傅德才[1] 王淑月[2] 荣杰[1] 张守芳[3] 

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018 [2]河北医科大学药学院,河北石家庄050017 [3]沈阳药科大学制药工程学院,辽宁沈阳110015

出　　处：《河北工业科技》2004年第3期55-57,共3页Hebei Journal of Industrial Science and Technology

摘　　要：NO是细胞间重要的信使物质,具有多种生理作用;将释放NO的物质与传统的非甾体的抗炎药连接起来,在保证疗效的情况下有可能克服传统的非甾体抗炎药的胃肠道副作用,因此有可能成为高效低毒的新非甾体抗炎药。20世纪90年代以来,NO释放型的非甾体抗炎药研究取得了很大进展,现就这方面的研究情况作一简要综述。The development of new non-steroid anti-inflammatory drugs (NSAIDs) with high efficiency and minimal toxicity is based on the discovery of NO , which is an important message substance and has various physiological effects. Compounds which combine traditional non-steroid anti-inflammatory drugs with NO-releasing substance would become new NSAIDs . The study has achieved a great development since 1990s. A brief review is presented.

关 键 词：非甾体抗炎药 前列腺素 NO NSAIDS 胃肠道 副作用 

分 类 号：R914.5[医药卫生—药物化学]